Chemical product design emerged as a key activity of chemical engineers. Essentially, all chemical-related designs should be considered as product design, with process design being a subset of the product development process. A useful classification that covers a wide range of chemical products consists of basic chemicals, industrial products and consumer-configured products. Another classification focused on usage properties makes the distinction between homogeneous and structured products. In this chapter, a framework is proposed for integrating product development with process design and manufacturing. A powerful systematic method for managing new product projects is Quality Function Development. The formalisation is achieved by the concept of House of Quality. A central issue in product development is the assessment of product properties, and the impact on the environment. The prediction of properties in a broad sense is assisted today by sophisticated computer methods such as QSPR (Quantitative Structure-Property Relationship) and QSAR (Quantitative Structure-Activity Relationship). The above issues are illustrated by comprehensive examples.