Chitosan-coated iron(III) oxide nanoparticles and tungsten disulfide quantum dots-immobilized Fiber-based WaveFlex Biosensor for Staphylococcus Aureus bacterial detection in real food samples

Xianzheng Lang, Ragini Singh, Qinghua Zeng, Jun Li, Daniele Tosi, Jan Nedoma, Carlos Marques, Bingyuan Zhang, Santosh Kumar

Research output: Contribution to journalArticlepeer-review

Abstract

The research proposes and investigates an extraordinarily sensitive, label-free WaveFlex biosensor utilizing optical fiber technology for the detection of Staphylococcus aureus (S. aureus), a common foodborne bacterium. The WaveFlex biosensor (plasmon Wave based Flexible optical fiber Biosensor) is based on a novel flexible tapered single-mode fiber structure, utilizing gold nanoparticles (AuNPs) to trigger the phenomenon of localized surface plasmon resonance (LSPR). Additionally, the sensitivity is further enhanced using chitosan-coated iron(III) oxide nanoparticles (Fe3O4–CS NPs) and tungsten disulfide quantum dots (WS2-QDs). The optical fiber surface is functionalized with antibodies to achieve specific detection of S. aureus. For S. aureus concentrations at 1 × 108 CFU/mL (colony-forming units per milliliter), the sensor's maximum sensitivity of 2.74 nm/lg (CFU/mL), and a detection limit (LOD) of 6.67 CFU/mL. This ultra-sensitive biosensor holds great potential for widespread applications in various fields, including disease detection, medical diagnostics, and food safety inspection.

Original languageEnglish
Article number100239
JournalSensors and Actuators Reports
Volume8
DOIs
Publication statusPublished - Dec 2024

Keywords

  • AuNPs
  • FeO –CS NPs
  • Optical fiber biosensors
  • S. aureus detection
  • WaveFlex biosensors

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Computer Science (miscellaneous)
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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