TY - JOUR
T1 - Chitosan-coated iron(III) oxide nanoparticles and tungsten disulfide quantum dots-immobilized Fiber-based WaveFlex Biosensor for Staphylococcus Aureus bacterial detection in real food samples
AU - Lang, Xianzheng
AU - Singh, Ragini
AU - Zeng, Qinghua
AU - Li, Jun
AU - Tosi, Daniele
AU - Nedoma, Jan
AU - Marques, Carlos
AU - Zhang, Bingyuan
AU - Kumar, Santosh
N1 - Publisher Copyright:
© 2024
PY - 2024/12
Y1 - 2024/12
N2 - The research proposes and investigates an extraordinarily sensitive, label-free WaveFlex biosensor utilizing optical fiber technology for the detection of Staphylococcus aureus (S. aureus), a common foodborne bacterium. The WaveFlex biosensor (plasmon Wave based Flexible optical fiber Biosensor) is based on a novel flexible tapered single-mode fiber structure, utilizing gold nanoparticles (AuNPs) to trigger the phenomenon of localized surface plasmon resonance (LSPR). Additionally, the sensitivity is further enhanced using chitosan-coated iron(III) oxide nanoparticles (Fe3O4–CS NPs) and tungsten disulfide quantum dots (WS2-QDs). The optical fiber surface is functionalized with antibodies to achieve specific detection of S. aureus. For S. aureus concentrations at 1 × 108 CFU/mL (colony-forming units per milliliter), the sensor's maximum sensitivity of 2.74 nm/lg (CFU/mL), and a detection limit (LOD) of 6.67 CFU/mL. This ultra-sensitive biosensor holds great potential for widespread applications in various fields, including disease detection, medical diagnostics, and food safety inspection.
AB - The research proposes and investigates an extraordinarily sensitive, label-free WaveFlex biosensor utilizing optical fiber technology for the detection of Staphylococcus aureus (S. aureus), a common foodborne bacterium. The WaveFlex biosensor (plasmon Wave based Flexible optical fiber Biosensor) is based on a novel flexible tapered single-mode fiber structure, utilizing gold nanoparticles (AuNPs) to trigger the phenomenon of localized surface plasmon resonance (LSPR). Additionally, the sensitivity is further enhanced using chitosan-coated iron(III) oxide nanoparticles (Fe3O4–CS NPs) and tungsten disulfide quantum dots (WS2-QDs). The optical fiber surface is functionalized with antibodies to achieve specific detection of S. aureus. For S. aureus concentrations at 1 × 108 CFU/mL (colony-forming units per milliliter), the sensor's maximum sensitivity of 2.74 nm/lg (CFU/mL), and a detection limit (LOD) of 6.67 CFU/mL. This ultra-sensitive biosensor holds great potential for widespread applications in various fields, including disease detection, medical diagnostics, and food safety inspection.
KW - AuNPs
KW - FeO –CS NPs
KW - Optical fiber biosensors
KW - S. aureus detection
KW - WaveFlex biosensors
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U2 - 10.1016/j.snr.2024.100239
DO - 10.1016/j.snr.2024.100239
M3 - Article
AN - SCOPUS:85202723884
SN - 2666-0539
VL - 8
JO - Sensors and Actuators Reports
JF - Sensors and Actuators Reports
M1 - 100239
ER -