Chromogenesis-based Resonance Raman molecular sensor for reactive oxygen species

Jeongyun Heo, Chang Keun Lim, Alexander Baev, Andrey N. Kuzmin, Soo Young Park, Paras N. Prasad, Sehoon Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Here we report a novel design concept for a molecular sensing platform that specifically generates under non-toxic visible laser excitation, resonance Raman signatures of nitrile (∼2200 cm-1) in response to reactive oxygen species (ROS). The sensing principle employs a ROS-triggered oxidative chromogenic reaction that activates resonance Raman enhancement through chemical transformation of a non-resonant hydrazo molecule into a resonant azo dye with extended π-conjugation. Experimental studies as well as DFT calculation demonstrate that such a design strategy for activatable resonance Raman sensor is valid for selective detection of highly oxidative ROS, hypochlorite ions in the present case, down to 100 ppm.

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalDyes and Pigments
Volume130
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • Bio-orthogonal Raman scattering
  • Hypochlorite
  • Raman sensor
  • Reactive oxygen species
  • Resonance Raman

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Process Chemistry and Technology

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