Abstract
We have studied the presence of chromogranins A and B and secretogranin II in medullary carcinomas of the thyroid using the methods of immunoblotting and immunohistochemistry. All three antigens were identified by immunoblotting. Chromogranin A and secretogranin II behaved identically to the adrenal antigens in electrophoresis, whereas the molecular size of chromogranin B in the thyroid tissue appeared slightly smaller, possibly due to a higher degree of proteolytic processing. In immunohistochemistry, positive staining was obtained with all three antigens throughout the tumor tissue. All three antigens, as well as the hormone calcitonin, were apparently present in the same cells. Our study suggests that in addition to chromogranin A, the other two antigens (chromogranin B and secretogranin II) may also be useful markers for tumors arising from endocrine tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 551-556 |
| Number of pages | 6 |
| Journal | American Journal of Surgical Pathology |
| Volume | 11 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
Cite this
Chromogranin A and B and secretogranin II in medullary carcinomas of the thyroid. / Schmid, K. W.; Fischer-Colbrie, R.; Hagn, C.; Jasani, B.; Williams, E. D.; Winkler, H.
In: American Journal of Surgical Pathology, Vol. 11, No. 7, 1987, p. 551-556.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chromogranin A and B and secretogranin II in medullary carcinomas of the thyroid
AU - Schmid, K. W.
AU - Fischer-Colbrie, R.
AU - Hagn, C.
AU - Jasani, B.
AU - Williams, E. D.
AU - Winkler, H.
PY - 1987
Y1 - 1987
N2 - We have studied the presence of chromogranins A and B and secretogranin II in medullary carcinomas of the thyroid using the methods of immunoblotting and immunohistochemistry. All three antigens were identified by immunoblotting. Chromogranin A and secretogranin II behaved identically to the adrenal antigens in electrophoresis, whereas the molecular size of chromogranin B in the thyroid tissue appeared slightly smaller, possibly due to a higher degree of proteolytic processing. In immunohistochemistry, positive staining was obtained with all three antigens throughout the tumor tissue. All three antigens, as well as the hormone calcitonin, were apparently present in the same cells. Our study suggests that in addition to chromogranin A, the other two antigens (chromogranin B and secretogranin II) may also be useful markers for tumors arising from endocrine tissues.
AB - We have studied the presence of chromogranins A and B and secretogranin II in medullary carcinomas of the thyroid using the methods of immunoblotting and immunohistochemistry. All three antigens were identified by immunoblotting. Chromogranin A and secretogranin II behaved identically to the adrenal antigens in electrophoresis, whereas the molecular size of chromogranin B in the thyroid tissue appeared slightly smaller, possibly due to a higher degree of proteolytic processing. In immunohistochemistry, positive staining was obtained with all three antigens throughout the tumor tissue. All three antigens, as well as the hormone calcitonin, were apparently present in the same cells. Our study suggests that in addition to chromogranin A, the other two antigens (chromogranin B and secretogranin II) may also be useful markers for tumors arising from endocrine tissues.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023268180&partnerID=8YFLogxK
U2 - 10.1097/00000478-198707000-00007
DO - 10.1097/00000478-198707000-00007
M3 - Article
VL - 11
SP - 551
EP - 556
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
SN - 0147-5185
IS - 7
ER -