Chronic neutrophilic leukemia and multiple myeloma: An association with λ light chain expression

Graham R. Standen, Bharat Jasani, Michael Wagstaff, Charles A.J. Wardrop

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46 Citations (Scopus)

Abstract

Two patients with plasma cell dyscrasia and IgG λ paraproteinemia in association with the rare disorder, chronic neutrophilic leukemia (CNL), are described. Cytogenetic studies excluded Philadelphia + chronic myeloid leukemia and molecular analysis of the breakpoint cluster region (bcr) revealed no evidence of clonal gene rearrangement. Nine similar cases of coexistent CNL and paraproteinemia have been identified in the literature and attention is drawn to the disproportionate excess of λ light chain restriction in this subset of patients. Evidence supporting a clonal origin of CNL is considered and the nature of the relationship between the chronic myeloid expansion and the development of multiple myeloma is discussed.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalCancer
Volume66
Issue number1
DOIs
Publication statusPublished - Jul 1 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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