Chronicles of a switch hunt

gcm genes in development

Michael Wegner, Dieter Riethmacher

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Co-conservation of sequence and function is an important principle during evolution. As a consequence, sequence-related genes often have similar functions in evolutionarily distant species. Enter the 'glial cells missing' (gcm) genes. They code for a small family of novel transcription factors that share DNA-binding properties and domain structure. However, no evolutionarily conserved function is apparent as yet. The prototypical gcm from Drosophila dominates nervous system development as a fate switch and master regulator of gliogenesis, whereas mammalian gcm genes have roles in placental morphogenesis and development of the parathyroid gland. Apparently, structure and function sometimes can go separate ways.

Original languageEnglish
Pages (from-to)286-290
Number of pages5
JournalTrends in Genetics
Volume17
Issue number5
DOIs
Publication statusPublished - May 1 2001
Externally publishedYes

Fingerprint

Neuroglia
Genes
Placentation
Parathyroid Glands
Morphogenesis
Nervous System
Drosophila
Transcription Factors
DNA

ASJC Scopus subject areas

  • Genetics

Cite this

Chronicles of a switch hunt : gcm genes in development. / Wegner, Michael; Riethmacher, Dieter.

In: Trends in Genetics, Vol. 17, No. 5, 01.05.2001, p. 286-290.

Research output: Contribution to journalArticle

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