Circulating microparticles: Square the circle

Natasha S. Barteneva, Elizaveta Fasler-Kan, Michael Bernimoulin, Joel N.H. Stern, Eugeny D. Ponomarev, Larry Duckett, Ivan A. Vorobjev

Research output: Contribution to journalReview articlepeer-review

161 Citations (Scopus)


Background: The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance.Results: MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50 and 1000 nm. MPs are capable of transferring peptides, proteins, lipid components, microRNA, mRNA, and DNA from one cell to another without direct cell-to-cell contact. Growing evidence suggests that MPs present in peripheral blood and body fluids contribute to the development and progression of cancer, and are of pathophysiological relevance for autoimmune, inflammatory, infectious, cardiovascular, hematological, and other diseases. MPs have large diagnostic potential as biomarkers; however, due to current technological limitations in purification of MPs and an absence of standardized methods of MP detection, challenges remain in validating the potential of MPs as a non-invasive and early diagnostic platform.Conclusions: Improvements in the effective deciphering of MP molecular signatures will be critical not only for diagnostics, but also for the evaluation of treatment regimens and predicting disease outcomes.

Original languageEnglish
Article number23
JournalBMC Cell Biology
Issue number1
Publication statusPublished - Apr 22 2013


  • Circulating
  • Diagnostics
  • Disease
  • Exosomes
  • Microparticles
  • Microvesicles
  • Therapy

ASJC Scopus subject areas

  • Cell Biology

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