TY - JOUR
T1 - Circulating microparticles
T2 - Square the circle
AU - Barteneva, Natasha S.
AU - Fasler-Kan, Elizaveta
AU - Bernimoulin, Michael
AU - Stern, Joel N.H.
AU - Ponomarev, Eugeny D.
AU - Duckett, Larry
AU - Vorobjev, Ivan A.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/4/22
Y1 - 2013/4/22
N2 - Background: The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance.Results: MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50 and 1000 nm. MPs are capable of transferring peptides, proteins, lipid components, microRNA, mRNA, and DNA from one cell to another without direct cell-to-cell contact. Growing evidence suggests that MPs present in peripheral blood and body fluids contribute to the development and progression of cancer, and are of pathophysiological relevance for autoimmune, inflammatory, infectious, cardiovascular, hematological, and other diseases. MPs have large diagnostic potential as biomarkers; however, due to current technological limitations in purification of MPs and an absence of standardized methods of MP detection, challenges remain in validating the potential of MPs as a non-invasive and early diagnostic platform.Conclusions: Improvements in the effective deciphering of MP molecular signatures will be critical not only for diagnostics, but also for the evaluation of treatment regimens and predicting disease outcomes.
AB - Background: The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance.Results: MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50 and 1000 nm. MPs are capable of transferring peptides, proteins, lipid components, microRNA, mRNA, and DNA from one cell to another without direct cell-to-cell contact. Growing evidence suggests that MPs present in peripheral blood and body fluids contribute to the development and progression of cancer, and are of pathophysiological relevance for autoimmune, inflammatory, infectious, cardiovascular, hematological, and other diseases. MPs have large diagnostic potential as biomarkers; however, due to current technological limitations in purification of MPs and an absence of standardized methods of MP detection, challenges remain in validating the potential of MPs as a non-invasive and early diagnostic platform.Conclusions: Improvements in the effective deciphering of MP molecular signatures will be critical not only for diagnostics, but also for the evaluation of treatment regimens and predicting disease outcomes.
KW - Circulating
KW - Diagnostics
KW - Disease
KW - Exosomes
KW - Microparticles
KW - Microvesicles
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=84876734176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876734176&partnerID=8YFLogxK
U2 - 10.1186/1471-2121-14-23
DO - 10.1186/1471-2121-14-23
M3 - Review article
C2 - 23607880
AN - SCOPUS:84876734176
VL - 14
JO - BMC Cell Biology
JF - BMC Cell Biology
SN - 1471-2121
IS - 1
M1 - 23
ER -