Class I and class II regions of the major histocompatibility complex both contribute to individual odors in congenic inbred strains of rats

R E Brown, B Roser, P B Singh

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The major histocompatibility complex (MHC) of the rat has three regions--A (class I), B/D (class II), and C/E (class I)--and congenic strains are available which differ in each of these regions. We used the habituation-dishabituation procedure to examine the ability of PVG-RT1u male rats to discriminate between the urinary odors of congenic rat strains which differ genetically only at certain individual regions of the MHC. The results of five experiments indicate that discrimination can be made between urine from rats which differ in all three regions of the MHC (PVG vs. PVG-RT1av1 donors), only in the class I A region (PVG vs. PVG.R1 donors), only in the class I C/E region (PVG.R19 vs. PVG-RT1av1 donors), only in the class II B/D region (PVG.R1 vs. PVG.R19 donors), and in all regions except the classical class IA locus (PVG-RT1av1 vs. PVG.R1 donors). These results indicate that all of the MHC regions may contribute to the individual odors of rats.

Original languageEnglish
Pages (from-to)659-74
Number of pages16
JournalBehavior Genetics
Volume19
Issue number5
Publication statusPublished - Sep 1989

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Inbred Strains Rats
major histocompatibility complex
Major Histocompatibility Complex
odor
odors
rats
habituation
urine
Odorants
E region
Urine
loci

Keywords

  • Animals
  • Genes, MHC Class I
  • Genes, MHC Class II
  • Major Histocompatibility Complex
  • Male
  • Odorants
  • Pheromones
  • Rats
  • Rats, Inbred Strains
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Class I and class II regions of the major histocompatibility complex both contribute to individual odors in congenic inbred strains of rats. / Brown, R E; Roser, B; Singh, P B.

In: Behavior Genetics, Vol. 19, No. 5, 09.1989, p. 659-74.

Research output: Contribution to journalArticle

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AU - Brown, R E

AU - Roser, B

AU - Singh, P B

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N2 - The major histocompatibility complex (MHC) of the rat has three regions--A (class I), B/D (class II), and C/E (class I)--and congenic strains are available which differ in each of these regions. We used the habituation-dishabituation procedure to examine the ability of PVG-RT1u male rats to discriminate between the urinary odors of congenic rat strains which differ genetically only at certain individual regions of the MHC. The results of five experiments indicate that discrimination can be made between urine from rats which differ in all three regions of the MHC (PVG vs. PVG-RT1av1 donors), only in the class I A region (PVG vs. PVG.R1 donors), only in the class I C/E region (PVG.R19 vs. PVG-RT1av1 donors), only in the class II B/D region (PVG.R1 vs. PVG.R19 donors), and in all regions except the classical class IA locus (PVG-RT1av1 vs. PVG.R1 donors). These results indicate that all of the MHC regions may contribute to the individual odors of rats.

AB - The major histocompatibility complex (MHC) of the rat has three regions--A (class I), B/D (class II), and C/E (class I)--and congenic strains are available which differ in each of these regions. We used the habituation-dishabituation procedure to examine the ability of PVG-RT1u male rats to discriminate between the urinary odors of congenic rat strains which differ genetically only at certain individual regions of the MHC. The results of five experiments indicate that discrimination can be made between urine from rats which differ in all three regions of the MHC (PVG vs. PVG-RT1av1 donors), only in the class I A region (PVG vs. PVG.R1 donors), only in the class I C/E region (PVG.R19 vs. PVG-RT1av1 donors), only in the class II B/D region (PVG.R1 vs. PVG.R19 donors), and in all regions except the classical class IA locus (PVG-RT1av1 vs. PVG.R1 donors). These results indicate that all of the MHC regions may contribute to the individual odors of rats.

KW - Animals

KW - Genes, MHC Class I

KW - Genes, MHC Class II

KW - Major Histocompatibility Complex

KW - Male

KW - Odorants

KW - Pheromones

KW - Rats

KW - Rats, Inbred Strains

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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VL - 19

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JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

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