Abstract
We report the case of a 9-year-old Senegalese girl with co-occurring wild-type (HBeAg-positive) chronic hepatitis B and antinuclear antibody-positive autoimmune hepatitis. Her HLA haplotype was A1, B8, DRB1*04, DQB1*02. Steriod and lamivudine therapy led to biochemical remission, and reactivation occurred when the patient stopped steroids. Persistent HBV infection due to wild-type virus (likely acquired vertically or early in life, as the mother was HBsAg positive) may have acted as a trigger for autoimmune hepatitis in this young girl.
| Original language | English |
|---|---|
| Pages (from-to) | 927-929 |
| Number of pages | 3 |
| Journal | European Journal of Gastroenterology and Hepatology |
| Volume | 18 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2006 |
| Externally published | Yes |
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Keywords
- Autoimmune hepatitis
- Chronic hepatitis
- Hepatitis B
ASJC Scopus subject areas
- Gastroenterology
Cite this
Co-occurrence of chronic hepatitis B virus infection and autoimmune hepatitis in a young Senegalese girl. / Nobili, Valerio; Marcellini, Matilde; Devito, Rita; Comparcola, Donatella; Vento, Sandro.
In: European Journal of Gastroenterology and Hepatology, Vol. 18, No. 8, 08.2006, p. 927-929.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Co-occurrence of chronic hepatitis B virus infection and autoimmune hepatitis in a young Senegalese girl
AU - Nobili, Valerio
AU - Marcellini, Matilde
AU - Devito, Rita
AU - Comparcola, Donatella
AU - Vento, Sandro
PY - 2006/8
Y1 - 2006/8
N2 - We report the case of a 9-year-old Senegalese girl with co-occurring wild-type (HBeAg-positive) chronic hepatitis B and antinuclear antibody-positive autoimmune hepatitis. Her HLA haplotype was A1, B8, DRB1*04, DQB1*02. Steriod and lamivudine therapy led to biochemical remission, and reactivation occurred when the patient stopped steroids. Persistent HBV infection due to wild-type virus (likely acquired vertically or early in life, as the mother was HBsAg positive) may have acted as a trigger for autoimmune hepatitis in this young girl.
AB - We report the case of a 9-year-old Senegalese girl with co-occurring wild-type (HBeAg-positive) chronic hepatitis B and antinuclear antibody-positive autoimmune hepatitis. Her HLA haplotype was A1, B8, DRB1*04, DQB1*02. Steriod and lamivudine therapy led to biochemical remission, and reactivation occurred when the patient stopped steroids. Persistent HBV infection due to wild-type virus (likely acquired vertically or early in life, as the mother was HBsAg positive) may have acted as a trigger for autoimmune hepatitis in this young girl.
KW - Autoimmune hepatitis
KW - Chronic hepatitis
KW - Hepatitis B
UR - http://www.scopus.com/inward/record.url?scp=33745806559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745806559&partnerID=8YFLogxK
U2 - 10.1097/00042737-200608000-00021
DO - 10.1097/00042737-200608000-00021
M3 - Article
VL - 18
SP - 927
EP - 929
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 8
ER -