Co-occurrence of chronic hepatitis B virus infection and autoimmune hepatitis in a young Senegalese girl

Valerio Nobili, Matilde Marcellini, Rita Devito, Donatella Comparcola, Sandro Vento

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report the case of a 9-year-old Senegalese girl with co-occurring wild-type (HBeAg-positive) chronic hepatitis B and antinuclear antibody-positive autoimmune hepatitis. Her HLA haplotype was A1, B8, DRB1*04, DQB1*02. Steriod and lamivudine therapy led to biochemical remission, and reactivation occurred when the patient stopped steroids. Persistent HBV infection due to wild-type virus (likely acquired vertically or early in life, as the mother was HBsAg positive) may have acted as a trigger for autoimmune hepatitis in this young girl.

Original languageEnglish
Pages (from-to)927-929
Number of pages3
JournalEuropean Journal of Gastroenterology and Hepatology
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 2006
Externally publishedYes

Fingerprint

Autoimmune Hepatitis
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Hepatitis B Antibodies
Lamivudine
Hepatitis B e Antigens
Antinuclear Antibodies
Hepatitis B Surface Antigens
Haplotypes
Steroids
Mothers
Viruses
Infection
Therapeutics

Keywords

  • Autoimmune hepatitis
  • Chronic hepatitis
  • Hepatitis B

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Co-occurrence of chronic hepatitis B virus infection and autoimmune hepatitis in a young Senegalese girl. / Nobili, Valerio; Marcellini, Matilde; Devito, Rita; Comparcola, Donatella; Vento, Sandro.

In: European Journal of Gastroenterology and Hepatology, Vol. 18, No. 8, 08.2006, p. 927-929.

Research output: Contribution to journalArticle

Nobili, Valerio ; Marcellini, Matilde ; Devito, Rita ; Comparcola, Donatella ; Vento, Sandro. / Co-occurrence of chronic hepatitis B virus infection and autoimmune hepatitis in a young Senegalese girl. In: European Journal of Gastroenterology and Hepatology. 2006 ; Vol. 18, No. 8. pp. 927-929.
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