We report the case of a 9-year-old Senegalese girl with co-occurring wild-type (HBeAg-positive) chronic hepatitis B and antinuclear antibody-positive autoimmune hepatitis. Her HLA haplotype was A1, B8, DRB1*04, DQB1*02. Steriod and lamivudine therapy led to biochemical remission, and reactivation occurred when the patient stopped steroids. Persistent HBV infection due to wild-type virus (likely acquired vertically or early in life, as the mother was HBsAg positive) may have acted as a trigger for autoimmune hepatitis in this young girl.
|Number of pages||3|
|Journal||European Journal of Gastroenterology and Hepatology|
|Publication status||Published - Aug 1 2006|
- Autoimmune hepatitis
- Chronic hepatitis
- Hepatitis B
ASJC Scopus subject areas