Co-occurrence of chronic hepatitis B virus infection and autoimmune hepatitis in a young Senegalese girl

Valerio Nobili, Matilde Marcellini, Rita Devito, Donatella Comparcola, Sandro Vento

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report the case of a 9-year-old Senegalese girl with co-occurring wild-type (HBeAg-positive) chronic hepatitis B and antinuclear antibody-positive autoimmune hepatitis. Her HLA haplotype was A1, B8, DRB1*04, DQB1*02. Steriod and lamivudine therapy led to biochemical remission, and reactivation occurred when the patient stopped steroids. Persistent HBV infection due to wild-type virus (likely acquired vertically or early in life, as the mother was HBsAg positive) may have acted as a trigger for autoimmune hepatitis in this young girl.

Original languageEnglish
Pages (from-to)927-929
Number of pages3
JournalEuropean Journal of Gastroenterology and Hepatology
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 1 2006

Keywords

  • Autoimmune hepatitis
  • Chronic hepatitis
  • Hepatitis B

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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