Coenzyme Q10 for enhancing physical activity and extending the human life cycle

Geir Bjørklund; Yuliya Semenova; Amin Gasmi; Neluwa-Liyanage Ruwan Indika; Ihor Hrynovets; Roman Lysiuk; Larysa Lenchyk; Taras Uryr; Hanna Yeromina; Massimiliano Peana

doi:10.2174/0929867330666230228103913

Coenzyme Q10 for enhancing physical activity and extending the human life cycle

Geir Bjørklund, Yuliya Semenova, Amin Gasmi, Neluwa-Liyanage Ruwan Indika, Ihor Hrynovets, Roman Lysiuk, Larysa Lenchyk, Taras Uryr, Hanna Yeromina, Massimiliano Peana

Nazarbayev University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

BACKGROUND: Coenzyme Q (CoQ) is an enzyme family that plays a crucial role in maintaining the electron transport chain and antioxidant defense. CoQ10 is the most common form of CoQ in humans. A deficiency of CoQ10 occurs naturally with aging and may contribute to the development or progression of many diseases. Besides, certain drugs, in particular, statins and bisphosphonates, interfere with the enzymes responsible for CoQ10 biosynthesis and, thus, lead to CoQ10deficiency.

OBJECTIVES: This article aims to evaluate the cumulative studies and insights on the topic of CoQ10 functions in human health, focusing on a potential role in maintaining physical activity and extending the life cycle.

RESULTS: Although supplementation with CoQ10offers many benefits to patients with cardiovascular disease, it appears to add little value to patients suffering from statin-associated muscular symptoms. This may be attributed to substantial heterogeneity in doses and treatment regimens used.

CONCLUSION: Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ10 in a range of health conditions and diseases.

Original language	English
Journal	Current Medicinal Chemistry
DOIs	https://doi.org/10.2174/0929867330666230228103913
Publication status	E-pub ahead of print - Feb 28 2023

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@article{46aab19c923b404aae706fe9ef6db787,

title = "Coenzyme Q10 for enhancing physical activity and extending the human life cycle",

abstract = "BACKGROUND: Coenzyme Q (CoQ) is an enzyme family that plays a crucial role in maintaining the electron transport chain and antioxidant defense. CoQ10 is the most common form of CoQ in humans. A deficiency of CoQ10 occurs naturally with aging and may contribute to the development or progression of many diseases. Besides, certain drugs, in particular, statins and bisphosphonates, interfere with the enzymes responsible for CoQ10 biosynthesis and, thus, lead to CoQ10deficiency.OBJECTIVES: This article aims to evaluate the cumulative studies and insights on the topic of CoQ10 functions in human health, focusing on a potential role in maintaining physical activity and extending the life cycle.RESULTS: Although supplementation with CoQ10offers many benefits to patients with cardiovascular disease, it appears to add little value to patients suffering from statin-associated muscular symptoms. This may be attributed to substantial heterogeneity in doses and treatment regimens used.CONCLUSION: Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ10 in a range of health conditions and diseases.",

author = "Geir Bj{\o}rklund and Yuliya Semenova and Amin Gasmi and {Ruwan Indika}, Neluwa-Liyanage and Ihor Hrynovets and Roman Lysiuk and Larysa Lenchyk and Taras Uryr and Hanna Yeromina and Massimiliano Peana",

note = "Copyright{\textcopyright} Bentham Science Publishers; For any queries, please email at [email protected].",

year = "2023",

month = feb,

day = "28",

doi = "10.2174/0929867330666230228103913",

language = "English",

journal = "Current Medicinal Chemistry",

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TY - JOUR

T1 - Coenzyme Q10 for enhancing physical activity and extending the human life cycle

AU - Bjørklund, Geir

AU - Semenova, Yuliya

AU - Gasmi, Amin

AU - Ruwan Indika, Neluwa-Liyanage

AU - Hrynovets, Ihor

AU - Lysiuk, Roman

AU - Lenchyk, Larysa

AU - Uryr, Taras

AU - Yeromina, Hanna

AU - Peana, Massimiliano

PY - 2023/2/28

Y1 - 2023/2/28

N2 - BACKGROUND: Coenzyme Q (CoQ) is an enzyme family that plays a crucial role in maintaining the electron transport chain and antioxidant defense. CoQ10 is the most common form of CoQ in humans. A deficiency of CoQ10 occurs naturally with aging and may contribute to the development or progression of many diseases. Besides, certain drugs, in particular, statins and bisphosphonates, interfere with the enzymes responsible for CoQ10 biosynthesis and, thus, lead to CoQ10deficiency.OBJECTIVES: This article aims to evaluate the cumulative studies and insights on the topic of CoQ10 functions in human health, focusing on a potential role in maintaining physical activity and extending the life cycle.RESULTS: Although supplementation with CoQ10offers many benefits to patients with cardiovascular disease, it appears to add little value to patients suffering from statin-associated muscular symptoms. This may be attributed to substantial heterogeneity in doses and treatment regimens used.CONCLUSION: Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ10 in a range of health conditions and diseases.

AB - BACKGROUND: Coenzyme Q (CoQ) is an enzyme family that plays a crucial role in maintaining the electron transport chain and antioxidant defense. CoQ10 is the most common form of CoQ in humans. A deficiency of CoQ10 occurs naturally with aging and may contribute to the development or progression of many diseases. Besides, certain drugs, in particular, statins and bisphosphonates, interfere with the enzymes responsible for CoQ10 biosynthesis and, thus, lead to CoQ10deficiency.OBJECTIVES: This article aims to evaluate the cumulative studies and insights on the topic of CoQ10 functions in human health, focusing on a potential role in maintaining physical activity and extending the life cycle.RESULTS: Although supplementation with CoQ10offers many benefits to patients with cardiovascular disease, it appears to add little value to patients suffering from statin-associated muscular symptoms. This may be attributed to substantial heterogeneity in doses and treatment regimens used.CONCLUSION: Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ10 in a range of health conditions and diseases.

U2 - 10.2174/0929867330666230228103913

DO - 10.2174/0929867330666230228103913

M3 - Article

C2 - 36852817

SN - 0929-8673

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

ER -

Coenzyme Q10 for enhancing physical activity and extending the human life cycle

Abstract

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