TY - JOUR
T1 - Colchicine toxicity in end-stage renal disease patients
T2 - A case-control study
AU - Solak, Yalcin
AU - Atalay, Huseyin
AU - Biyik, Zeynep
AU - Alibasic, Hayrudin
AU - Gaipov, Abduzhappar
AU - Guney, Figen
AU - Kucuk, Adem
AU - Tonbul, Halil Zeki
AU - Yeksan, Mehdi
AU - Turk, Suleyman
PY - 2014/12/4
Y1 - 2014/12/4
N2 - Colchicine has been used in a number of disorders. Because colchicine is partially excreted from the kidney, there is a need for dose reduction in case of renal functional impairment. There are no data with regards to safe dosing schedule of colchicine in hemodialysis patients. We aimed to evaluate adverse effects of colchicine use in a hemodialysis cohort. We screened hemodialysis patients who were using colchicine for any reason. All patients were interviewed regarding possible toxicities of colchicine use and were examined with a special focus on neuromuscular system. Creatine kinase and myoglobin were used to detect any subclinical muscle injury or rhabdomyolysis, respectively. Twenty-two maintenance hemodialysis patients who were on colchicine for more than 6 months and 20 control hemodialysis patients not using colchicine were included in the study. Four of 22 patients were using 0.5 mg/day, 4 patients were using 1.5 mg/day, and 14 patients were using 1 mg/day colchicine. Mean duration for colchicine use was 8.9 ± 8.2 years. There was no difference between the groups in terms of myoneuropathic signs and symptoms and blood counts except for white blood cell count, which was significantly higher in patients on colchicine. Serum creatine kinase (56.3 ± 39.5 and 52.1 ± 36.1 for colchicine and control groups, respectively, P = 0.72) and myoglobin (191.4 ± 108.8 and 214.6 ± 83.5 for colchicine and control groups, respectively, P = 0.44) levels were not different between the groups. We conclude that in a small number of haemodialysis patients who were apparently tolerating colchicine, detailed assessment revealed no evidence of sublinical toxicity when compared with controls.
AB - Colchicine has been used in a number of disorders. Because colchicine is partially excreted from the kidney, there is a need for dose reduction in case of renal functional impairment. There are no data with regards to safe dosing schedule of colchicine in hemodialysis patients. We aimed to evaluate adverse effects of colchicine use in a hemodialysis cohort. We screened hemodialysis patients who were using colchicine for any reason. All patients were interviewed regarding possible toxicities of colchicine use and were examined with a special focus on neuromuscular system. Creatine kinase and myoglobin were used to detect any subclinical muscle injury or rhabdomyolysis, respectively. Twenty-two maintenance hemodialysis patients who were on colchicine for more than 6 months and 20 control hemodialysis patients not using colchicine were included in the study. Four of 22 patients were using 0.5 mg/day, 4 patients were using 1.5 mg/day, and 14 patients were using 1 mg/day colchicine. Mean duration for colchicine use was 8.9 ± 8.2 years. There was no difference between the groups in terms of myoneuropathic signs and symptoms and blood counts except for white blood cell count, which was significantly higher in patients on colchicine. Serum creatine kinase (56.3 ± 39.5 and 52.1 ± 36.1 for colchicine and control groups, respectively, P = 0.72) and myoglobin (191.4 ± 108.8 and 214.6 ± 83.5 for colchicine and control groups, respectively, P = 0.44) levels were not different between the groups. We conclude that in a small number of haemodialysis patients who were apparently tolerating colchicine, detailed assessment revealed no evidence of sublinical toxicity when compared with controls.
KW - Adverse effect
KW - Colchicine
KW - Hemodialysis
KW - Toxicity
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U2 - 10.1097/MJT.0b013e31825a364a
DO - 10.1097/MJT.0b013e31825a364a
M3 - Article
C2 - 22874645
AN - SCOPUS:84914157803
VL - 21
SP - e189-e195
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
SN - 1075-2765
IS - 6
ER -