Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients

G. Di Perri, A. Cazzadori, S. Vento, S. Bonora, M. Malena, L. Bontempini, M. Lanzafame, B. Allegranzi, E. Concia

Research output: Contribution to journalArticle

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Abstract

Setting: Clinical features of human immunodeficiency virus (HIV)-associated tuberculosis depend upon the patients' residual immunity. An immune-dependent presentation has also been described at the histopathological level in many extra-pulmonary sites, but no descriptions have so far been made on the histopathology of HIV-associated pulmonary tuberculosis. Objective: To compare the histopathological features of pulmonary tuberculosis in HIV-infected subjects and seronegative patients. Design: We carried out a retrospective comparative study on 16 HIV-infected subjects and 16 seronegative patients with culture-proven pulmonary tuberculosis who underwent transbronchial biopsy. We evaluated the bacillary burden and the parenchymal inflammatory reaction by means of a four-graded scoring system giving an approximate quantitative measure of the two parameters. Results: HIV-associated pulmonary tuberculosis was found to differ significantly from disease forms seen in seronegative patients, with a significant tendency to develop highly bacillary and poorly reactive histopathological pictures along with the downgrading evolution of immune function. Conclusion: Pathologic features of pulmonary tuberculosis in HIV-infected subjects differ from those encountered in seronegative patients depending upon the individual immunity of the former. HIV-associated progressive depletion of CD4+ lymphocytes leads to substantial changes in pulmonary reactivity to Mycobacterium tuberculosis; multibacillary pictures in a background of loose inflammatory reactions are quite common findings at the extreme phase of HIV-related immune deterioration.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalTubercle and Lung Disease
Volume77
Issue number3
DOIs
Publication statusPublished - 1996
Externally publishedYes

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Pulmonary Tuberculosis
HIV
Immunity
Lymphocyte Depletion
Lung
Mycobacterium tuberculosis
Tuberculosis
Retrospective Studies
Biopsy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology
  • Microbiology

Cite this

Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients. / Di Perri, G.; Cazzadori, A.; Vento, S.; Bonora, S.; Malena, M.; Bontempini, L.; Lanzafame, M.; Allegranzi, B.; Concia, E.

In: Tubercle and Lung Disease, Vol. 77, No. 3, 1996, p. 244-249.

Research output: Contribution to journalArticle

Di Perri, G, Cazzadori, A, Vento, S, Bonora, S, Malena, M, Bontempini, L, Lanzafame, M, Allegranzi, B & Concia, E 1996, 'Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients', Tubercle and Lung Disease, vol. 77, no. 3, pp. 244-249. https://doi.org/10.1016/S0962-8479(96)90008-8
Di Perri, G. ; Cazzadori, A. ; Vento, S. ; Bonora, S. ; Malena, M. ; Bontempini, L. ; Lanzafame, M. ; Allegranzi, B. ; Concia, E. / Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients. In: Tubercle and Lung Disease. 1996 ; Vol. 77, No. 3. pp. 244-249.
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