Abstract
Setting: Clinical features of human immunodeficiency virus (HIV)-associated tuberculosis depend upon the patients' residual immunity. An immune-dependent presentation has also been described at the histopathological level in many extra-pulmonary sites, but no descriptions have so far been made on the histopathology of HIV-associated pulmonary tuberculosis. Objective: To compare the histopathological features of pulmonary tuberculosis in HIV-infected subjects and seronegative patients. Design: We carried out a retrospective comparative study on 16 HIV-infected subjects and 16 seronegative patients with culture-proven pulmonary tuberculosis who underwent transbronchial biopsy. We evaluated the bacillary burden and the parenchymal inflammatory reaction by means of a four-graded scoring system giving an approximate quantitative measure of the two parameters. Results: HIV-associated pulmonary tuberculosis was found to differ significantly from disease forms seen in seronegative patients, with a significant tendency to develop highly bacillary and poorly reactive histopathological pictures along with the downgrading evolution of immune function. Conclusion: Pathologic features of pulmonary tuberculosis in HIV-infected subjects differ from those encountered in seronegative patients depending upon the individual immunity of the former. HIV-associated progressive depletion of CD4+ lymphocytes leads to substantial changes in pulmonary reactivity to Mycobacterium tuberculosis; multibacillary pictures in a background of loose inflammatory reactions are quite common findings at the extreme phase of HIV-related immune deterioration.
| Original language | English |
|---|---|
| Pages (from-to) | 244-249 |
| Number of pages | 6 |
| Journal | Tubercle and Lung Disease |
| Volume | 77 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Immunology
- Microbiology
Cite this
Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients. / Di Perri, G.; Cazzadori, A.; Vento, S.; Bonora, S.; Malena, M.; Bontempini, L.; Lanzafame, M.; Allegranzi, B.; Concia, E.
In: Tubercle and Lung Disease, Vol. 77, No. 3, 1996, p. 244-249.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients
AU - Di Perri, G.
AU - Cazzadori, A.
AU - Vento, S.
AU - Bonora, S.
AU - Malena, M.
AU - Bontempini, L.
AU - Lanzafame, M.
AU - Allegranzi, B.
AU - Concia, E.
PY - 1996
Y1 - 1996
N2 - Setting: Clinical features of human immunodeficiency virus (HIV)-associated tuberculosis depend upon the patients' residual immunity. An immune-dependent presentation has also been described at the histopathological level in many extra-pulmonary sites, but no descriptions have so far been made on the histopathology of HIV-associated pulmonary tuberculosis. Objective: To compare the histopathological features of pulmonary tuberculosis in HIV-infected subjects and seronegative patients. Design: We carried out a retrospective comparative study on 16 HIV-infected subjects and 16 seronegative patients with culture-proven pulmonary tuberculosis who underwent transbronchial biopsy. We evaluated the bacillary burden and the parenchymal inflammatory reaction by means of a four-graded scoring system giving an approximate quantitative measure of the two parameters. Results: HIV-associated pulmonary tuberculosis was found to differ significantly from disease forms seen in seronegative patients, with a significant tendency to develop highly bacillary and poorly reactive histopathological pictures along with the downgrading evolution of immune function. Conclusion: Pathologic features of pulmonary tuberculosis in HIV-infected subjects differ from those encountered in seronegative patients depending upon the individual immunity of the former. HIV-associated progressive depletion of CD4+ lymphocytes leads to substantial changes in pulmonary reactivity to Mycobacterium tuberculosis; multibacillary pictures in a background of loose inflammatory reactions are quite common findings at the extreme phase of HIV-related immune deterioration.
AB - Setting: Clinical features of human immunodeficiency virus (HIV)-associated tuberculosis depend upon the patients' residual immunity. An immune-dependent presentation has also been described at the histopathological level in many extra-pulmonary sites, but no descriptions have so far been made on the histopathology of HIV-associated pulmonary tuberculosis. Objective: To compare the histopathological features of pulmonary tuberculosis in HIV-infected subjects and seronegative patients. Design: We carried out a retrospective comparative study on 16 HIV-infected subjects and 16 seronegative patients with culture-proven pulmonary tuberculosis who underwent transbronchial biopsy. We evaluated the bacillary burden and the parenchymal inflammatory reaction by means of a four-graded scoring system giving an approximate quantitative measure of the two parameters. Results: HIV-associated pulmonary tuberculosis was found to differ significantly from disease forms seen in seronegative patients, with a significant tendency to develop highly bacillary and poorly reactive histopathological pictures along with the downgrading evolution of immune function. Conclusion: Pathologic features of pulmonary tuberculosis in HIV-infected subjects differ from those encountered in seronegative patients depending upon the individual immunity of the former. HIV-associated progressive depletion of CD4+ lymphocytes leads to substantial changes in pulmonary reactivity to Mycobacterium tuberculosis; multibacillary pictures in a background of loose inflammatory reactions are quite common findings at the extreme phase of HIV-related immune deterioration.
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U2 - 10.1016/S0962-8479(96)90008-8
DO - 10.1016/S0962-8479(96)90008-8
M3 - Article
VL - 77
SP - 244
EP - 249
JO - Tuberculosis
JF - Tuberculosis
SN - 1472-9792
IS - 3
ER -