Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients

G. Di Perri, A. Cazzadori, S. Vento, S. Bonora, M. Malena, L. Bontempini, M. Lanzafame, B. Allegranzi, E. Concia

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Setting: Clinical features of human immunodeficiency virus (HIV)-associated tuberculosis depend upon the patients' residual immunity. An immune-dependent presentation has also been described at the histopathological level in many extra-pulmonary sites, but no descriptions have so far been made on the histopathology of HIV-associated pulmonary tuberculosis. Objective: To compare the histopathological features of pulmonary tuberculosis in HIV-infected subjects and seronegative patients. Design: We carried out a retrospective comparative study on 16 HIV-infected subjects and 16 seronegative patients with culture-proven pulmonary tuberculosis who underwent transbronchial biopsy. We evaluated the bacillary burden and the parenchymal inflammatory reaction by means of a four-graded scoring system giving an approximate quantitative measure of the two parameters. Results: HIV-associated pulmonary tuberculosis was found to differ significantly from disease forms seen in seronegative patients, with a significant tendency to develop highly bacillary and poorly reactive histopathological pictures along with the downgrading evolution of immune function. Conclusion: Pathologic features of pulmonary tuberculosis in HIV-infected subjects differ from those encountered in seronegative patients depending upon the individual immunity of the former. HIV-associated progressive depletion of CD4+ lymphocytes leads to substantial changes in pulmonary reactivity to Mycobacterium tuberculosis; multibacillary pictures in a background of loose inflammatory reactions are quite common findings at the extreme phase of HIV-related immune deterioration.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalTubercle and Lung Disease
Volume77
Issue number3
DOIs
Publication statusPublished - Jan 1 1996

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients'. Together they form a unique fingerprint.

  • Cite this

    Di Perri, G., Cazzadori, A., Vento, S., Bonora, S., Malena, M., Bontempini, L., Lanzafame, M., Allegranzi, B., & Concia, E. (1996). Comparative histopathological study of pulmonary tuberculosis in human immunodeficiency virus-infected and non-infected patients. Tubercle and Lung Disease, 77(3), 244-249. https://doi.org/10.1016/S0962-8479(96)90008-8