Comparison of Custodiol vs warm blood cardioplegia and conditioning of donor hearts during transportation with the organ care system

Rymbay Kaliyev, Timur Lesbekov, Serik Bekbossynov, Makhabbat Bekbossynova, Zhuldyz Nurmykhametova, Svetlana Novikova, Nurlan Smagulov, Assel Medressova, Linar Faizov, Zhanibek Ashyrov, Philip la Fleur, Robertas Samalavicius, Yuriy Pya

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Cold crystalloid cardioplegia for donor heart harvesting and cold ischemic storage conditions during the transportation is the standard of care during heart transplantation procedure. Organ care system (OCS) was introduced for more prolonged and reliable ex vivo organ management. This study evaluated the two different techniques used for myocardial preservation during the procurement and transportation of the heart using the OCS.

METHODS: We performed prospective analysis of 43 patients with heart failure undergoing heart transplantation and using the OCS for donor organ transport. Donor hearts were arrested using blood cardioplegia and conditioning (n = 30) or standard Custodiol (SC) solution ( n = 13). Perfusion and cardiac function parameters were continuously monitored while the donor hearts were perfused in the OCS. Impact of preservation techniques on biochemical parameters and clinical outcomes were evaluated.

RESULTS: All donor hearts had stable perfusion and lactate characteristics in the OCS, with similar measures between the two groups at the beginning of the ex vivo perfusion. Ex vivo heart perfusion mean ending concentration of Interleukin (IL)-6 and IL-8 was significantly lower in the blood cardioplegia group compared to the standard care group. Clinical outcomes were comparable between the two groups of patients.

CONCLUSIONS: The use of blood cardioplegia and conditioning could be a safe method for myocardial protection in distant procurement and preservation of donor hearts in the OCS.

Original languageEnglish
JournalJournal of Cardiac Surgery
DOIs
Publication statusE-pub ahead of print - Jul 23 2019
Externally publishedYes

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Induced Heart Arrest
Tissue Donors
Perfusion
Heart Transplantation
Standard of Care
Blood Group Antigens
Interleukin-8
Lactic Acid
Interleukin-6
Heart Failure

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Comparison of Custodiol vs warm blood cardioplegia and conditioning of donor hearts during transportation with the organ care system. / Kaliyev, Rymbay; Lesbekov, Timur; Bekbossynov, Serik; Bekbossynova, Makhabbat; Nurmykhametova, Zhuldyz; Novikova, Svetlana; Smagulov, Nurlan; Medressova, Assel; Faizov, Linar; Ashyrov, Zhanibek; la Fleur, Philip; Samalavicius, Robertas; Pya, Yuriy.

In: Journal of Cardiac Surgery, 23.07.2019.

Research output: Contribution to journalArticle

Kaliyev, R, Lesbekov, T, Bekbossynov, S, Bekbossynova, M, Nurmykhametova, Z, Novikova, S, Smagulov, N, Medressova, A, Faizov, L, Ashyrov, Z, la Fleur, P, Samalavicius, R & Pya, Y 2019, 'Comparison of Custodiol vs warm blood cardioplegia and conditioning of donor hearts during transportation with the organ care system', Journal of Cardiac Surgery. https://doi.org/10.1111/jocs.14162
Kaliyev, Rymbay ; Lesbekov, Timur ; Bekbossynov, Serik ; Bekbossynova, Makhabbat ; Nurmykhametova, Zhuldyz ; Novikova, Svetlana ; Smagulov, Nurlan ; Medressova, Assel ; Faizov, Linar ; Ashyrov, Zhanibek ; la Fleur, Philip ; Samalavicius, Robertas ; Pya, Yuriy. / Comparison of Custodiol vs warm blood cardioplegia and conditioning of donor hearts during transportation with the organ care system. In: Journal of Cardiac Surgery. 2019.
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abstract = "OBJECTIVES: Cold crystalloid cardioplegia for donor heart harvesting and cold ischemic storage conditions during the transportation is the standard of care during heart transplantation procedure. Organ care system (OCS) was introduced for more prolonged and reliable ex vivo organ management. This study evaluated the two different techniques used for myocardial preservation during the procurement and transportation of the heart using the OCS.METHODS: We performed prospective analysis of 43 patients with heart failure undergoing heart transplantation and using the OCS for donor organ transport. Donor hearts were arrested using blood cardioplegia and conditioning (n = 30) or standard Custodiol (SC) solution ( n = 13). Perfusion and cardiac function parameters were continuously monitored while the donor hearts were perfused in the OCS. Impact of preservation techniques on biochemical parameters and clinical outcomes were evaluated.RESULTS: All donor hearts had stable perfusion and lactate characteristics in the OCS, with similar measures between the two groups at the beginning of the ex vivo perfusion. Ex vivo heart perfusion mean ending concentration of Interleukin (IL)-6 and IL-8 was significantly lower in the blood cardioplegia group compared to the standard care group. Clinical outcomes were comparable between the two groups of patients.CONCLUSIONS: The use of blood cardioplegia and conditioning could be a safe method for myocardial protection in distant procurement and preservation of donor hearts in the OCS.",
author = "Rymbay Kaliyev and Timur Lesbekov and Serik Bekbossynov and Makhabbat Bekbossynova and Zhuldyz Nurmykhametova and Svetlana Novikova and Nurlan Smagulov and Assel Medressova and Linar Faizov and Zhanibek Ashyrov and {la Fleur}, Philip and Robertas Samalavicius and Yuriy Pya",
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T1 - Comparison of Custodiol vs warm blood cardioplegia and conditioning of donor hearts during transportation with the organ care system

AU - Kaliyev, Rymbay

AU - Lesbekov, Timur

AU - Bekbossynov, Serik

AU - Bekbossynova, Makhabbat

AU - Nurmykhametova, Zhuldyz

AU - Novikova, Svetlana

AU - Smagulov, Nurlan

AU - Medressova, Assel

AU - Faizov, Linar

AU - Ashyrov, Zhanibek

AU - la Fleur, Philip

AU - Samalavicius, Robertas

AU - Pya, Yuriy

N1 - © 2019 The Authors. Journal of Cardiac Surgery Published by Wiley Periodicals, Inc.

PY - 2019/7/23

Y1 - 2019/7/23

N2 - OBJECTIVES: Cold crystalloid cardioplegia for donor heart harvesting and cold ischemic storage conditions during the transportation is the standard of care during heart transplantation procedure. Organ care system (OCS) was introduced for more prolonged and reliable ex vivo organ management. This study evaluated the two different techniques used for myocardial preservation during the procurement and transportation of the heart using the OCS.METHODS: We performed prospective analysis of 43 patients with heart failure undergoing heart transplantation and using the OCS for donor organ transport. Donor hearts were arrested using blood cardioplegia and conditioning (n = 30) or standard Custodiol (SC) solution ( n = 13). Perfusion and cardiac function parameters were continuously monitored while the donor hearts were perfused in the OCS. Impact of preservation techniques on biochemical parameters and clinical outcomes were evaluated.RESULTS: All donor hearts had stable perfusion and lactate characteristics in the OCS, with similar measures between the two groups at the beginning of the ex vivo perfusion. Ex vivo heart perfusion mean ending concentration of Interleukin (IL)-6 and IL-8 was significantly lower in the blood cardioplegia group compared to the standard care group. Clinical outcomes were comparable between the two groups of patients.CONCLUSIONS: The use of blood cardioplegia and conditioning could be a safe method for myocardial protection in distant procurement and preservation of donor hearts in the OCS.

AB - OBJECTIVES: Cold crystalloid cardioplegia for donor heart harvesting and cold ischemic storage conditions during the transportation is the standard of care during heart transplantation procedure. Organ care system (OCS) was introduced for more prolonged and reliable ex vivo organ management. This study evaluated the two different techniques used for myocardial preservation during the procurement and transportation of the heart using the OCS.METHODS: We performed prospective analysis of 43 patients with heart failure undergoing heart transplantation and using the OCS for donor organ transport. Donor hearts were arrested using blood cardioplegia and conditioning (n = 30) or standard Custodiol (SC) solution ( n = 13). Perfusion and cardiac function parameters were continuously monitored while the donor hearts were perfused in the OCS. Impact of preservation techniques on biochemical parameters and clinical outcomes were evaluated.RESULTS: All donor hearts had stable perfusion and lactate characteristics in the OCS, with similar measures between the two groups at the beginning of the ex vivo perfusion. Ex vivo heart perfusion mean ending concentration of Interleukin (IL)-6 and IL-8 was significantly lower in the blood cardioplegia group compared to the standard care group. Clinical outcomes were comparable between the two groups of patients.CONCLUSIONS: The use of blood cardioplegia and conditioning could be a safe method for myocardial protection in distant procurement and preservation of donor hearts in the OCS.

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