Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 595-601 |
| Number of pages | 7 |
| Journal | Science of the Total Environment |
| Volume | 692 |
| DOIs | |
| Publication status | Published - Nov 20 2019 |
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Keywords
- Certified reference soils
- Contaminated soils
- Heavy metals
- in vitro dermal bioaccessibility
- Synthetic sebum
- Synthetic sweat
Cite this
Comparison of five artificial skin surface film liquids for assessing dermal bioaccessibility of metals in certified reference soils. / Marin Villegas, Carlos A.; Guney, Mert; Zagury, Gerald J.
In: Science of the Total Environment, Vol. 692, 20.11.2019, p. 595-601.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Comparison of five artificial skin surface film liquids for assessing dermal bioaccessibility of metals in certified reference soils
AU - Marin Villegas, Carlos A.
AU - Guney, Mert
AU - Zagury, Gerald J.
PY - 2019/11/20
Y1 - 2019/11/20
N2 - © 2019 Dermal exposure to metals has previously received less attention than oral/inhalation exposure. Nonetheless, human health risk is significant for certain contaminants and exposure scenarios. The present study aims to (1) characterize two certified reference soils (SQC001, BGS 102); and (2) assess Cr, Ni, Pb, and Zn dermal bioaccessibility via in vitro assays using three synthetic sweat formulations (EN 1811, pH 6.5 (Sweat A), NIHS 96-10, pH 4.7 (Sweat B), and a more complex pH 5.5 formulation containing amino acids (Sweat C)) and two sebum formulations. Metals bioaccessibility in sweat followed Sweat B > Sweat C > Sweat A, attributed to sweat B lower pH. Dermal bioaccessibility in both sebum formulations was lower than 1% for Ni and Pb and below 9% for Cr and Zn, possibly due to low affinity of metals for non-polar lipids. It must be noted that bioaccessible Zn in BGS 102 was higher when extracted with synthetic sebum compared to any of the synthetic sweat formulations. Metal bioaccessibility in sweat was considerably higher for SQC001 (up to 76.6% for Zn using Sweat B) than for BGS 102 (ranging between 0.02 and 1.3% for all elements and all sweat formulations), attributed to higher pH, higher organic carbon, and higher cation exchange capacity of reference soil BGS 102. Sebum formulations spiked with metals generally entailed low metal recovery (except for Zn), which may explain overall low bioaccessibility values for sebum. Sebum and sweat formulation, and soil properties seem to control in vitro dermal bioaccessibility of metals.
AB - © 2019 Dermal exposure to metals has previously received less attention than oral/inhalation exposure. Nonetheless, human health risk is significant for certain contaminants and exposure scenarios. The present study aims to (1) characterize two certified reference soils (SQC001, BGS 102); and (2) assess Cr, Ni, Pb, and Zn dermal bioaccessibility via in vitro assays using three synthetic sweat formulations (EN 1811, pH 6.5 (Sweat A), NIHS 96-10, pH 4.7 (Sweat B), and a more complex pH 5.5 formulation containing amino acids (Sweat C)) and two sebum formulations. Metals bioaccessibility in sweat followed Sweat B > Sweat C > Sweat A, attributed to sweat B lower pH. Dermal bioaccessibility in both sebum formulations was lower than 1% for Ni and Pb and below 9% for Cr and Zn, possibly due to low affinity of metals for non-polar lipids. It must be noted that bioaccessible Zn in BGS 102 was higher when extracted with synthetic sebum compared to any of the synthetic sweat formulations. Metal bioaccessibility in sweat was considerably higher for SQC001 (up to 76.6% for Zn using Sweat B) than for BGS 102 (ranging between 0.02 and 1.3% for all elements and all sweat formulations), attributed to higher pH, higher organic carbon, and higher cation exchange capacity of reference soil BGS 102. Sebum formulations spiked with metals generally entailed low metal recovery (except for Zn), which may explain overall low bioaccessibility values for sebum. Sebum and sweat formulation, and soil properties seem to control in vitro dermal bioaccessibility of metals.
KW - Certified reference soils
KW - Contaminated soils
KW - Heavy metals
KW - in vitro dermal bioaccessibility
KW - Synthetic sebum
KW - Synthetic sweat
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U2 - 10.1016/j.scitotenv.2019.07.281
DO - 10.1016/j.scitotenv.2019.07.281
M3 - Article
VL - 692
SP - 595
EP - 601
JO - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
ER -