Comparison of tumour markers in malignant mesothelioma and pulmonary adenocarcinoma

A. R. Gibbs, R. Harach, J. C. Wagner, B. Jasani

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Immunohistological methods were used to investigate the presence of carcinoembryonic antigen, β1 pregnancy specific glycoprotein, β subunit of human chorionic gonadotrophin, human placental lactogen, calcitonin, and keratin in formalin fixed tissue from 29 malignant mesotheliomas and 27 pulmonary adenocarcinomas. Malignant mesotheliomas were negative for tumour markers except for the β subunit of human chorionic gonadotrophin and keratin, one and 13 cases respectively being positive for these. Pulmonary adenocarcinomas, however, were frequently positive for tumour markers - namely, carcinoembryonic antigen (24), β1 pregnancy specific glycoprotein (23), β subunit of human chorionic gonadotrophin (8), human placental lactogen (2), calcitonin (3), and keratin (12). The presence of carcinoembryonic antigen and β1 pregnancy specific glycoprotein within an intrathoracic tumour is strong evidence against its being of mesothelial origin.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalThorax
Volume40
Issue number2
Publication statusPublished - 1985
Externally publishedYes

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Carcinoembryonic Antigen
Chorionic Gonadotropin
Tumor Biomarkers
Placental Lactogen
Glycoproteins
Calcitonin
Pregnancy
Keratin-12
Keratin-13
Keratins
Formaldehyde
Malignant Mesothelioma
Adenocarcinoma of lung
Neoplasms

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Gibbs, A. R., Harach, R., Wagner, J. C., & Jasani, B. (1985). Comparison of tumour markers in malignant mesothelioma and pulmonary adenocarcinoma. Thorax, 40(2), 91-95.

Comparison of tumour markers in malignant mesothelioma and pulmonary adenocarcinoma. / Gibbs, A. R.; Harach, R.; Wagner, J. C.; Jasani, B.

In: Thorax, Vol. 40, No. 2, 1985, p. 91-95.

Research output: Contribution to journalArticle

Gibbs, AR, Harach, R, Wagner, JC & Jasani, B 1985, 'Comparison of tumour markers in malignant mesothelioma and pulmonary adenocarcinoma', Thorax, vol. 40, no. 2, pp. 91-95.
Gibbs AR, Harach R, Wagner JC, Jasani B. Comparison of tumour markers in malignant mesothelioma and pulmonary adenocarcinoma. Thorax. 1985;40(2):91-95.
Gibbs, A. R. ; Harach, R. ; Wagner, J. C. ; Jasani, B. / Comparison of tumour markers in malignant mesothelioma and pulmonary adenocarcinoma. In: Thorax. 1985 ; Vol. 40, No. 2. pp. 91-95.
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