Conjugation of polymers to proteins through an inhibitor-derived peptide: Taking up the inhibitor "berth"

Zengchao Tang; Dan Li; Yafei Luan; Lijuan Zhu; Hui Du; Yunwen Tao; Yanwei Wang; David M. Haddleton; Hong Chen

doi:10.1039/c5cc02659h

Conjugation of polymers to proteins through an inhibitor-derived peptide: Taking up the inhibitor "berth"

Zengchao Tang, Dan Li, Yafei Luan, Lijuan Zhu, Hui Du, Yunwen Tao, Yanwei Wang, David M. Haddleton, Hong Chen

Department of Chemical and Materials Engineering

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A hexapeptide derived from an enzyme inhibitor was used as an affinity ligand for the conjugation of a hydrophilic polymer to the enzyme. The peptide targeted the polymer to the "berth" of the inhibitor in the enzyme, affording the enzyme resistance to the inhibitor without affecting the enzymatic activity.

Original language	English
Pages (from-to)	10099-10102
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	50
DOIs	https://doi.org/10.1039/c5cc02659h
Publication status	Published - May 28 2015

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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Conjugation of polymers to proteins through an inhibitor-derived peptide : Taking up the inhibitor "berth". / Tang, Zengchao; Li, Dan; Luan, Yafei; Zhu, Lijuan; Du, Hui; Tao, Yunwen; Wang, Yanwei; Haddleton, David M.; Chen, Hong.

In: Chemical Communications, Vol. 51, No. 50, 28.05.2015, p. 10099-10102.

Research output: Contribution to journal › Article › peer-review

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