Conjugation of polymers to proteins through an inhibitor-derived peptide: Taking up the inhibitor "berth"

Zengchao Tang, Dan Li, Yafei Luan, Lijuan Zhu, Hui Du, Yunwen Tao, Yanwei Wang, David M. Haddleton, Hong Chen

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A hexapeptide derived from an enzyme inhibitor was used as an affinity ligand for the conjugation of a hydrophilic polymer to the enzyme. The peptide targeted the polymer to the "berth" of the inhibitor in the enzyme, affording the enzyme resistance to the inhibitor without affecting the enzymatic activity.

Original languageEnglish
Pages (from-to)10099-10102
Number of pages4
JournalChemical Communications
Volume51
Issue number50
DOIs
Publication statusPublished - May 28 2015

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Conjugation of polymers to proteins through an inhibitor-derived peptide: Taking up the inhibitor "berth"'. Together they form a unique fingerprint.

Cite this