Construction and evaluation of nitric oxide generating vascular graft material loaded with organoselenium catalyst via layer-by-layer self-assembly

Jun An, SiYuan Y. Chen, JingChen C. Gao, Xu Zhang, YuanYuan Y. Wang, YanDong D. Li, Sergey Mikhalovsky, DeLing L. Kong, ShuFang F. Wang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A new biomimetic material for artificial blood vessel with in situ catalytic generation of nitric oxide (NO) was prepared in this study. Organoselenium immobilized polyethyleneimine as NO donor catalyst and sodium alginate were alternately loaded onto the surface of electrospun polycaprolactone matrix via electrostatic layer-by-layer self-assembly. This material revealed significant NO generation when contacting NO donor S-nitrosoglutathione (GSNO). Adhesion and spreading of smooth muscle cells were inhibited on this material in the presence of GSNO, while proliferation of endothelial cells was promoted. In vitro platelet adhesion and arteriovenous shunt experiments demonstrated good antithrombotic properties of this material, with inhibited platelet activation and aggregation, and prevention of acute thrombosis. This study may provide a new method of improving cellular function and antithrombotic property of vascular grafts.

Original languageEnglish
Pages (from-to)765-772
Number of pages8
JournalScience China Life Sciences
Volume58
Issue number8
DOIs
Publication statusPublished - May 26 2015
Externally publishedYes

Fingerprint

Nitric Oxide Donors
nitric oxide
catalysts
blood vessels
Grafts
Self assembly
Blood Vessels
Biomimetic Materials
Nitric Oxide
catalyst
S-Nitrosoglutathione
Platelets
Transplants
Blood Substitutes
Polyethyleneimine
Catalysts
Blood vessel prostheses
Platelet Activation
Adhesion
Biomimetic materials

Keywords

  • biocompatibility
  • catalytic generation
  • electrospinning
  • nitric oxide
  • vascular graft

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Construction and evaluation of nitric oxide generating vascular graft material loaded with organoselenium catalyst via layer-by-layer self-assembly. / An, Jun; Chen, SiYuan Y.; Gao, JingChen C.; Zhang, Xu; Wang, YuanYuan Y.; Li, YanDong D.; Mikhalovsky, Sergey; Kong, DeLing L.; Wang, ShuFang F.

In: Science China Life Sciences, Vol. 58, No. 8, 26.05.2015, p. 765-772.

Research output: Contribution to journalArticle

An, Jun ; Chen, SiYuan Y. ; Gao, JingChen C. ; Zhang, Xu ; Wang, YuanYuan Y. ; Li, YanDong D. ; Mikhalovsky, Sergey ; Kong, DeLing L. ; Wang, ShuFang F. / Construction and evaluation of nitric oxide generating vascular graft material loaded with organoselenium catalyst via layer-by-layer self-assembly. In: Science China Life Sciences. 2015 ; Vol. 58, No. 8. pp. 765-772.
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AU - Li, YanDong D.

AU - Mikhalovsky, Sergey

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