[Contribution acknowledged as statistical analysis contributor and writing of manuscript] Individualised renal artery denervation improves blood pressure control in Kazakhstani patients with resistant hypertension

Marat Aripov, Abdurashid Mussayev, Serik Alimbayev, Alexey Goncharov, Gulnara Zhusupova, Yuriy Pya

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The prevalence of hypertension in Kazakhstan is high, and the majority of patients are not adequately controlled. Treatment with renal artery denervation (RAD) could represent a useful therapeutic option for a subset of patients in Kazakhstan with resistant hypertension.

AIM: To assess the impact of RAD in a cohort of patients from Kazakhstan with resistant hypertension.

METHODS: Between March 2012 and December 2013, 63 patients underwent RAD at our tertiary care centre. Eligibility criteria were office blood pressure more than 160 mm Hg systolic (SBP) or more than 90 mm Hg diastolic (DBP) despite being treated with three or more antihypertensive medications, including a diuretic. Ambulatory blood pressure was measured at baseline and at month 12, and monitoring also included impact on insulin resistance and renal function.

RESULTS: There were significant decreases of 25 ± 24 mm Hg for ambulatory SBP during the daytime and of 26 ± 23 mm Hg for ambulatory SBP during the nighttime (p < 0.0001). We observed significant decreases of 12 ± 14 mm Hg for ambula-tory daytime DBP and of 11 ± 14 mm Hg in ambulatory nighttime DBP (p < 0.0001). A decrease in creatinine clearance was observed from 100.2 ± 33.6 mL/min at baseline to 90.2 ± 22.8 mL/min at month 12 (p < 0.001). Homeostasis model assessment-insulin resistance (HOMA-IR) decreased from 3.0 ± 4.6 at baseline to 2.5 ± 3.7 at 12 months (p = 0.007).

CONCLUSIONS: In this population RAD resulted in statistically and clinically significant blood pressure reduction at 12 months with minimal adverse events.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalKardiologia Polska
Volume75
Issue number2
DOIs
Publication statusPublished - Jun 8 2017
Externally publishedYes

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Manuscripts
Denervation
Kazakhstan
Renal Artery
Blood Pressure
Hypertension
Insulin Resistance
Diuretics
Tertiary Care Centers
Antihypertensive Agents
Creatinine
Homeostasis
Kidney
Therapeutics
Population

Keywords

  • Adult
  • Aged
  • Blood Pressure Monitoring, Ambulatory
  • Coronary Vasospasm/surgery
  • Denervation/adverse effects
  • Female
  • Humans
  • Hypertension/surgery
  • Kazakhstan
  • Male
  • Middle Aged
  • Renal Artery/innervation
  • Treatment Outcome

Cite this

[Contribution acknowledged as statistical analysis contributor and writing of manuscript] Individualised renal artery denervation improves blood pressure control in Kazakhstani patients with resistant hypertension. / Aripov, Marat; Mussayev, Abdurashid; Alimbayev, Serik; Goncharov, Alexey; Zhusupova, Gulnara; Pya, Yuriy.

In: Kardiologia Polska, Vol. 75, No. 2, 08.06.2017, p. 101-107.

Research output: Contribution to journalArticle

Aripov, Marat ; Mussayev, Abdurashid ; Alimbayev, Serik ; Goncharov, Alexey ; Zhusupova, Gulnara ; Pya, Yuriy. / [Contribution acknowledged as statistical analysis contributor and writing of manuscript] Individualised renal artery denervation improves blood pressure control in Kazakhstani patients with resistant hypertension. In: Kardiologia Polska. 2017 ; Vol. 75, No. 2. pp. 101-107.
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T1 - [Contribution acknowledged as statistical analysis contributor and writing of manuscript] Individualised renal artery denervation improves blood pressure control in Kazakhstani patients with resistant hypertension

AU - Aripov, Marat

AU - Mussayev, Abdurashid

AU - Alimbayev, Serik

AU - Goncharov, Alexey

AU - Zhusupova, Gulnara

AU - Pya, Yuriy

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N2 - BACKGROUND: The prevalence of hypertension in Kazakhstan is high, and the majority of patients are not adequately controlled. Treatment with renal artery denervation (RAD) could represent a useful therapeutic option for a subset of patients in Kazakhstan with resistant hypertension.AIM: To assess the impact of RAD in a cohort of patients from Kazakhstan with resistant hypertension.METHODS: Between March 2012 and December 2013, 63 patients underwent RAD at our tertiary care centre. Eligibility criteria were office blood pressure more than 160 mm Hg systolic (SBP) or more than 90 mm Hg diastolic (DBP) despite being treated with three or more antihypertensive medications, including a diuretic. Ambulatory blood pressure was measured at baseline and at month 12, and monitoring also included impact on insulin resistance and renal function.RESULTS: There were significant decreases of 25 ± 24 mm Hg for ambulatory SBP during the daytime and of 26 ± 23 mm Hg for ambulatory SBP during the nighttime (p < 0.0001). We observed significant decreases of 12 ± 14 mm Hg for ambula-tory daytime DBP and of 11 ± 14 mm Hg in ambulatory nighttime DBP (p < 0.0001). A decrease in creatinine clearance was observed from 100.2 ± 33.6 mL/min at baseline to 90.2 ± 22.8 mL/min at month 12 (p < 0.001). Homeostasis model assessment-insulin resistance (HOMA-IR) decreased from 3.0 ± 4.6 at baseline to 2.5 ± 3.7 at 12 months (p = 0.007).CONCLUSIONS: In this population RAD resulted in statistically and clinically significant blood pressure reduction at 12 months with minimal adverse events.

AB - BACKGROUND: The prevalence of hypertension in Kazakhstan is high, and the majority of patients are not adequately controlled. Treatment with renal artery denervation (RAD) could represent a useful therapeutic option for a subset of patients in Kazakhstan with resistant hypertension.AIM: To assess the impact of RAD in a cohort of patients from Kazakhstan with resistant hypertension.METHODS: Between March 2012 and December 2013, 63 patients underwent RAD at our tertiary care centre. Eligibility criteria were office blood pressure more than 160 mm Hg systolic (SBP) or more than 90 mm Hg diastolic (DBP) despite being treated with three or more antihypertensive medications, including a diuretic. Ambulatory blood pressure was measured at baseline and at month 12, and monitoring also included impact on insulin resistance and renal function.RESULTS: There were significant decreases of 25 ± 24 mm Hg for ambulatory SBP during the daytime and of 26 ± 23 mm Hg for ambulatory SBP during the nighttime (p < 0.0001). We observed significant decreases of 12 ± 14 mm Hg for ambula-tory daytime DBP and of 11 ± 14 mm Hg in ambulatory nighttime DBP (p < 0.0001). A decrease in creatinine clearance was observed from 100.2 ± 33.6 mL/min at baseline to 90.2 ± 22.8 mL/min at month 12 (p < 0.001). Homeostasis model assessment-insulin resistance (HOMA-IR) decreased from 3.0 ± 4.6 at baseline to 2.5 ± 3.7 at 12 months (p = 0.007).CONCLUSIONS: In this population RAD resulted in statistically and clinically significant blood pressure reduction at 12 months with minimal adverse events.

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KW - Aged

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KW - Denervation/adverse effects

KW - Female

KW - Humans

KW - Hypertension/surgery

KW - Kazakhstan

KW - Male

KW - Middle Aged

KW - Renal Artery/innervation

KW - Treatment Outcome

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DO - 10.5603/KP.a2016.0096

M3 - Article

C2 - 27296285

VL - 75

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JO - Kardiologia Polska

JF - Kardiologia Polska

SN - 0022-9032

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ER -