Controlled release with coating layer of permeable particles

Ryusei Ito, Boris Golman, Kunio Shinohara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

An enhanced method was proposed for controlled release of core material using a coating layer of fine permeable particles dispersed in an impermeable wax prepared by dry-based process. A mathematical model was constructed to describe in detail the core material release by diffusion through the connected permeable particles inside the coating layer. The effective diffusivity was simulated by a random walk method taking into account the structure of the coating layer. The released characteristics were measured for the urea core particle coated with the layer of the starch permeable particles dispersed in the paraffin wax. The calculated results were in a good quantitative agreement with experimental data in all range of coating conditions. As a result, the low release rate was proven to be obtained with thicker coating layer of lower volume fraction of permeable particles. Moreover, the application of permeable particles instead of soluble ones [J. Chem. Eng. Jpn. 35 (2002) 40] resulted in significant decrease in release rate.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalJournal of Controlled Release
Volume92
Issue number3
DOIs
Publication statusPublished - Oct 30 2003
Externally publishedYes

Fingerprint

Waxes
Starch
Paraffin
Urea
Theoretical Models

Keywords

  • Coating layer
  • Controlled release
  • Mathematical model
  • Permeable particles
  • Random walk simulation

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Controlled release with coating layer of permeable particles. / Ito, Ryusei; Golman, Boris; Shinohara, Kunio.

In: Journal of Controlled Release, Vol. 92, No. 3, 30.10.2003, p. 361-368.

Research output: Contribution to journalArticle

Ito, Ryusei ; Golman, Boris ; Shinohara, Kunio. / Controlled release with coating layer of permeable particles. In: Journal of Controlled Release. 2003 ; Vol. 92, No. 3. pp. 361-368.
@article{f0c5bf332c6947e0802d13af1dcaaab2,
title = "Controlled release with coating layer of permeable particles",
abstract = "An enhanced method was proposed for controlled release of core material using a coating layer of fine permeable particles dispersed in an impermeable wax prepared by dry-based process. A mathematical model was constructed to describe in detail the core material release by diffusion through the connected permeable particles inside the coating layer. The effective diffusivity was simulated by a random walk method taking into account the structure of the coating layer. The released characteristics were measured for the urea core particle coated with the layer of the starch permeable particles dispersed in the paraffin wax. The calculated results were in a good quantitative agreement with experimental data in all range of coating conditions. As a result, the low release rate was proven to be obtained with thicker coating layer of lower volume fraction of permeable particles. Moreover, the application of permeable particles instead of soluble ones [J. Chem. Eng. Jpn. 35 (2002) 40] resulted in significant decrease in release rate.",
keywords = "Coating layer, Controlled release, Mathematical model, Permeable particles, Random walk simulation",
author = "Ryusei Ito and Boris Golman and Kunio Shinohara",
year = "2003",
month = "10",
day = "30",
doi = "10.1016/S0168-3659(03)00363-8",
language = "English",
volume = "92",
pages = "361--368",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Controlled release with coating layer of permeable particles

AU - Ito, Ryusei

AU - Golman, Boris

AU - Shinohara, Kunio

PY - 2003/10/30

Y1 - 2003/10/30

N2 - An enhanced method was proposed for controlled release of core material using a coating layer of fine permeable particles dispersed in an impermeable wax prepared by dry-based process. A mathematical model was constructed to describe in detail the core material release by diffusion through the connected permeable particles inside the coating layer. The effective diffusivity was simulated by a random walk method taking into account the structure of the coating layer. The released characteristics were measured for the urea core particle coated with the layer of the starch permeable particles dispersed in the paraffin wax. The calculated results were in a good quantitative agreement with experimental data in all range of coating conditions. As a result, the low release rate was proven to be obtained with thicker coating layer of lower volume fraction of permeable particles. Moreover, the application of permeable particles instead of soluble ones [J. Chem. Eng. Jpn. 35 (2002) 40] resulted in significant decrease in release rate.

AB - An enhanced method was proposed for controlled release of core material using a coating layer of fine permeable particles dispersed in an impermeable wax prepared by dry-based process. A mathematical model was constructed to describe in detail the core material release by diffusion through the connected permeable particles inside the coating layer. The effective diffusivity was simulated by a random walk method taking into account the structure of the coating layer. The released characteristics were measured for the urea core particle coated with the layer of the starch permeable particles dispersed in the paraffin wax. The calculated results were in a good quantitative agreement with experimental data in all range of coating conditions. As a result, the low release rate was proven to be obtained with thicker coating layer of lower volume fraction of permeable particles. Moreover, the application of permeable particles instead of soluble ones [J. Chem. Eng. Jpn. 35 (2002) 40] resulted in significant decrease in release rate.

KW - Coating layer

KW - Controlled release

KW - Mathematical model

KW - Permeable particles

KW - Random walk simulation

UR - http://www.scopus.com/inward/record.url?scp=1642347971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642347971&partnerID=8YFLogxK

U2 - 10.1016/S0168-3659(03)00363-8

DO - 10.1016/S0168-3659(03)00363-8

M3 - Article

C2 - 14568416

AN - SCOPUS:1642347971

VL - 92

SP - 361

EP - 368

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

IS - 3

ER -