Copper-Catalyzed Reaction of Secondary Propargylamines with Ethyl Buta-2,3-dienoate for the Synthesis of 1,6-Dihydropyridines

Chao Liu, Gaigai Wang, Yuqing Wang, Olga P. Pereshivko, Vsevolod A. Peshkov

Research output: Contribution to journalArticle

Abstract

A copper(I) bromide-catalyzed reaction of A 3 -coupling-derived propargylamines with ethyl buta-2,3-dienoate for the fast assembly of a 1,6-dihydropyridine core is described. The developed protocol was tested on a variety of secondary propargylamines and the possibility of a one-pot synthesis of 1,6-dihydropyridine through the A 3 -coupling and subsequent ethyl buta-2,3-dienoate incorporation was investigated.

Original languageEnglish
Pages (from-to)1981-1985
Number of pages5
JournalEuropean Journal of Organic Chemistry
Volume2019
Issue number10
DOIs
Publication statusPublished - Mar 14 2019

Fingerprint

Dihydropyridines
Copper
copper
synthesis
Bromides
bromides
assembly
propargylamine
1,4-dihydropyridine

Keywords

  • Allenes
  • Copper
  • Cyclization
  • Dihydropyridines
  • Propargylamines

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Copper-Catalyzed Reaction of Secondary Propargylamines with Ethyl Buta-2,3-dienoate for the Synthesis of 1,6-Dihydropyridines. / Liu, Chao; Wang, Gaigai; Wang, Yuqing; Pereshivko, Olga P.; Peshkov, Vsevolod A.

In: European Journal of Organic Chemistry, Vol. 2019, No. 10, 14.03.2019, p. 1981-1985.

Research output: Contribution to journalArticle

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AU - Peshkov, Vsevolod A.

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