Abstract
A copper(I) bromide-catalyzed reaction of A 3 -coupling-derived propargylamines with ethyl buta-2,3-dienoate for the fast assembly of a 1,6-dihydropyridine core is described. The developed protocol was tested on a variety of secondary propargylamines and the possibility of a one-pot synthesis of 1,6-dihydropyridine through the A 3 -coupling and subsequent ethyl buta-2,3-dienoate incorporation was investigated.
| Original language | English |
|---|---|
| Pages (from-to) | 1981-1985 |
| Number of pages | 5 |
| Journal | European Journal of Organic Chemistry |
| Volume | 2019 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Mar 14 2019 |
Funding
This work was supported by the start-up fund from Soochow University (grant Q410900714), National Natural Science Foundation of China (grant 21650110445), Natural Science Foundation of Jiangsu Province of China (grants BK20160310 and BK20150317), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and the Project of Scientific and Technologic Infrastructure of Suzhou (grant SZS201708).
Keywords
- Allenes
- Copper
- Cyclization
- Dihydropyridines
- Propargylamines
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
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