Copy-number variation of housekeeping gene rpl13a in rat strains selected for nervous system excitability

Ruslan Kalendar; Alexander Belyayev; Tatiana Zachepilo; Alexander Vaido; Dmitry Maidanyuk; Alan H. Schulman; Natalia Dyuzhikova

doi:10.1016/j.mcp.2017.02.004

Copy-number variation of housekeeping gene rpl13a in rat strains selected for nervous system excitability

Ruslan Kalendar, Alexander Belyayev, Tatiana Zachepilo, Alexander Vaido, Dmitry Maidanyuk, Alan H. Schulman, Natalia Dyuzhikova

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We evaluated copy number variation (CNV) for four genes in rat strains differing in nervous system excitability. rpl13a copy number is significantly reduced in hippocampus and bone marrow in rats with a high excitability threshold and stress. The observed phenomenon may be associated with a role for rpl13a in lipid metabolism.

Original language	English
Pages (from-to)	11-15
Number of pages	5
Journal	Molecular and Cellular Probes
Volume	33
DOIs	https://doi.org/10.1016/j.mcp.2017.02.004
Publication status	Published - Jun 2017
Externally published	Yes

Keywords

Bone marrow
Copy number variation (CNV)
Hippocampus
Nervous system excitability
Quantitative real-time multicolor multiplex PCR (qmPCR)
Rat

ASJC Scopus subject areas

Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.mcp.2017.02.004

Cite this

@article{18c2004c15d143c79b4a9a440a5dde02,

title = "Copy-number variation of housekeeping gene rpl13a in rat strains selected for nervous system excitability",

abstract = "We evaluated copy number variation (CNV) for four genes in rat strains differing in nervous system excitability. rpl13a copy number is significantly reduced in hippocampus and bone marrow in rats with a high excitability threshold and stress. The observed phenomenon may be associated with a role for rpl13a in lipid metabolism.",

keywords = "Bone marrow, Copy number variation (CNV), Hippocampus, Nervous system excitability, Quantitative real-time multicolor multiplex PCR (qmPCR), Rat",

author = "Ruslan Kalendar and Alexander Belyayev and Tatiana Zachepilo and Alexander Vaido and Dmitry Maidanyuk and Schulman, {Alan H.} and Natalia Dyuzhikova",

note = "Funding Information: Anne-Mari Narvanto is thanked for her excellent technical assistance. The work was supported by the Academy of Finland [Grant 134079] and by the Immanuel Kant Baltic Federal University [Grant L-2015-75993]. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2017",

month = jun,

doi = "10.1016/j.mcp.2017.02.004",

language = "English",

volume = "33",

pages = "11--15",

journal = "Molecular and Cellular Probes",

issn = "0890-8508",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Copy-number variation of housekeeping gene rpl13a in rat strains selected for nervous system excitability

AU - Kalendar, Ruslan

AU - Belyayev, Alexander

AU - Zachepilo, Tatiana

AU - Vaido, Alexander

AU - Maidanyuk, Dmitry

AU - Schulman, Alan H.

AU - Dyuzhikova, Natalia

N1 - Funding Information: Anne-Mari Narvanto is thanked for her excellent technical assistance. The work was supported by the Academy of Finland [Grant 134079] and by the Immanuel Kant Baltic Federal University [Grant L-2015-75993]. Publisher Copyright: © 2017 Elsevier Ltd Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/6

Y1 - 2017/6

N2 - We evaluated copy number variation (CNV) for four genes in rat strains differing in nervous system excitability. rpl13a copy number is significantly reduced in hippocampus and bone marrow in rats with a high excitability threshold and stress. The observed phenomenon may be associated with a role for rpl13a in lipid metabolism.

AB - We evaluated copy number variation (CNV) for four genes in rat strains differing in nervous system excitability. rpl13a copy number is significantly reduced in hippocampus and bone marrow in rats with a high excitability threshold and stress. The observed phenomenon may be associated with a role for rpl13a in lipid metabolism.

KW - Bone marrow

KW - Copy number variation (CNV)

KW - Hippocampus

KW - Nervous system excitability

KW - Quantitative real-time multicolor multiplex PCR (qmPCR)

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=85012879206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012879206&partnerID=8YFLogxK

U2 - 10.1016/j.mcp.2017.02.004

DO - 10.1016/j.mcp.2017.02.004

M3 - Article

C2 - 28192165

AN - SCOPUS:85012879206

SN - 0890-8508

VL - 33

SP - 11

EP - 15

JO - Molecular and Cellular Probes

JF - Molecular and Cellular Probes

ER -

Copy-number variation of housekeeping gene rpl13a in rat strains selected for nervous system excitability

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this