Copy-number variation of housekeeping gene rpl13a in rat strains selected for nervous system excitability

Ruslan Kalendar, Alexander Belyayev, Tatiana Zachepilo, Alexander Vaido, Dmitry Maidanyuk, Alan H. Schulman, Natalia Dyuzhikova

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We evaluated copy number variation (CNV) for four genes in rat strains differing in nervous system excitability. rpl13a copy number is significantly reduced in hippocampus and bone marrow in rats with a high excitability threshold and stress. The observed phenomenon may be associated with a role for rpl13a in lipid metabolism.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalMolecular and Cellular Probes
Volume33
DOIs
Publication statusPublished - Jun 2017
Externally publishedYes

Keywords

  • Bone marrow
  • Copy number variation (CNV)
  • Hippocampus
  • Nervous system excitability
  • Quantitative real-time multicolor multiplex PCR (qmPCR)
  • Rat

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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