Cosegregation of polymorphic DNA markers with arterial blood pressure in the ISIAH hypertensive rats

A. A. Krivenko; M. L. Filipenko; V. A. Adarichev; L. N. Maslova; V. V. Bulygina; G. M. Dymshits; A. L. Markel

Cosegregation of polymorphic DNA markers with arterial blood pressure in the ISIAH hypertensive rats

A. A. Krivenko, M. L. Filipenko, V. A. Adarichev, L. N. Maslova, V. V. Bulygina, G. M. Dymshits, A. L. Markel

Research output: Contribution to journal › Article › peer-review

Abstract

A search for DNA markers of hereditary arterial hypertension in ISIAH rats was performed by means of contemporary molecular genetic approaches. The backcross rat population used for the analyses was derived from a cross of the Wistar x ISIAH Fl progeny with the Wistar rats. Hybridization of the //tfelll-digested DNA samples with the (CAC)5 microsatellite probe revealed cosegregation of the basal arterial pressure value with the 4.8-kb polymorphic DNA fragment. Examination of the DNA polymorphism by means of polymerase chain reaction with arbitrary primers showed an association of the 700-bp polymorphic DNA fragment with the increase of arterial blood pressure under conditions of emotional stress.

Original language	English
Pages (from-to)	164-169
Number of pages	6
Journal	Genetika
Volume	35
Issue number	2
Publication status	Published - Dec 1 1999
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "Cosegregation of polymorphic DNA markers with arterial blood pressure in the ISIAH hypertensive rats",

abstract = "A search for DNA markers of hereditary arterial hypertension in ISIAH rats was performed by means of contemporary molecular genetic approaches. The backcross rat population used for the analyses was derived from a cross of the Wistar x ISIAH Fl progeny with the Wistar rats. Hybridization of the //tfelll-digested DNA samples with the (CAC)5 microsatellite probe revealed cosegregation of the basal arterial pressure value with the 4.8-kb polymorphic DNA fragment. Examination of the DNA polymorphism by means of polymerase chain reaction with arbitrary primers showed an association of the 700-bp polymorphic DNA fragment with the increase of arterial blood pressure under conditions of emotional stress.",

author = "Krivenko, {A. A.} and Filipenko, {M. L.} and Adarichev, {V. A.} and Maslova, {L. N.} and Bulygina, {V. V.} and Dymshits, {G. M.} and Markel, {A. L.}",

year = "1999",

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T1 - Cosegregation of polymorphic DNA markers with arterial blood pressure in the ISIAH hypertensive rats

AU - Krivenko, A. A.

AU - Filipenko, M. L.

AU - Adarichev, V. A.

AU - Maslova, L. N.

AU - Bulygina, V. V.

AU - Dymshits, G. M.

AU - Markel, A. L.

PY - 1999/12/1

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N2 - A search for DNA markers of hereditary arterial hypertension in ISIAH rats was performed by means of contemporary molecular genetic approaches. The backcross rat population used for the analyses was derived from a cross of the Wistar x ISIAH Fl progeny with the Wistar rats. Hybridization of the //tfelll-digested DNA samples with the (CAC)5 microsatellite probe revealed cosegregation of the basal arterial pressure value with the 4.8-kb polymorphic DNA fragment. Examination of the DNA polymorphism by means of polymerase chain reaction with arbitrary primers showed an association of the 700-bp polymorphic DNA fragment with the increase of arterial blood pressure under conditions of emotional stress.

AB - A search for DNA markers of hereditary arterial hypertension in ISIAH rats was performed by means of contemporary molecular genetic approaches. The backcross rat population used for the analyses was derived from a cross of the Wistar x ISIAH Fl progeny with the Wistar rats. Hybridization of the //tfelll-digested DNA samples with the (CAC)5 microsatellite probe revealed cosegregation of the basal arterial pressure value with the 4.8-kb polymorphic DNA fragment. Examination of the DNA polymorphism by means of polymerase chain reaction with arbitrary primers showed an association of the 700-bp polymorphic DNA fragment with the increase of arterial blood pressure under conditions of emotional stress.

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