TY - JOUR
T1 - Cost-Effective Fiber Optic Solutions for Biosensing
AU - Leitão, Cátia
AU - Pereira, Sónia O.
AU - Marques, Carlos
AU - Cennamo, Nunzio
AU - Zeni, Luigi
AU - Shaimerdenova, Madina
AU - Ayupova, Takhmina
AU - Tosi, Daniele
N1 - Funding Information:
The authors acknowledge financial support of the project i3N, UIDB/50025/2020, UIDP/50025/2020, and LA/P/0037/2020, and DigiAqua project (PTDC/EEI-EEE/0415/2021) financed by national funds through the FCT/MEC. C. Marques and C. Leitão thank FCT through the CEEIND/00034/2018 (iFish project) and CEEIND/00154/2020 research contracts, respectively. S. O. Pereira thanks i3N for the BPD grant BPD/UI96/5808/2017. The work was also funded by Nazarbayev University, under SMARTER (code: 091019CRP2117) and EPICGuide (code: 240919FD3908) grants.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/8
Y1 - 2022/8
N2 - In the last years, optical fiber sensors have proven to be a reliable and versatile biosensing tool. Optical fiber biosensors (OFBs) are analytical devices that use optical fibers as transducers, with the advantages of being easily coated and biofunctionalized, allowing the monitorization of all functionalization and detection in real-time, as well as being small in size and geometrically flexible, thus allowing device miniaturization and portability for point-of-care (POC) testing. Knowing the potential of such biosensing tools, this paper reviews the reported OFBs which are, at the moment, the most cost-effective. Different fiber configurations are highlighted, namely, end-face reflected, unclad, D- and U-shaped, tips, ball resonators, tapered, light-diffusing, and specialty fibers. Packaging techniques to enhance OFBs’ application in the medical field, namely for implementing in subcutaneous, percutaneous, and endoscopic operations as well as in wearable structures, are presented and discussed. Interrogation approaches of OFBs using smartphones’ hardware are a great way to obtain cost-effective sensing approaches. In this review paper, different architectures of such interrogation methods and their respective applications are presented. Finally, the application of OFBs in monitoring three crucial fields of human life and wellbeing are reported: detection of cancer biomarkers, detection of cardiovascular biomarkers, and environmental monitoring.
AB - In the last years, optical fiber sensors have proven to be a reliable and versatile biosensing tool. Optical fiber biosensors (OFBs) are analytical devices that use optical fibers as transducers, with the advantages of being easily coated and biofunctionalized, allowing the monitorization of all functionalization and detection in real-time, as well as being small in size and geometrically flexible, thus allowing device miniaturization and portability for point-of-care (POC) testing. Knowing the potential of such biosensing tools, this paper reviews the reported OFBs which are, at the moment, the most cost-effective. Different fiber configurations are highlighted, namely, end-face reflected, unclad, D- and U-shaped, tips, ball resonators, tapered, light-diffusing, and specialty fibers. Packaging techniques to enhance OFBs’ application in the medical field, namely for implementing in subcutaneous, percutaneous, and endoscopic operations as well as in wearable structures, are presented and discussed. Interrogation approaches of OFBs using smartphones’ hardware are a great way to obtain cost-effective sensing approaches. In this review paper, different architectures of such interrogation methods and their respective applications are presented. Finally, the application of OFBs in monitoring three crucial fields of human life and wellbeing are reported: detection of cancer biomarkers, detection of cardiovascular biomarkers, and environmental monitoring.
KW - cancer biomarkers
KW - cardiovascular biomarkers
KW - environmental monitoring
KW - optical interrogation methods
KW - POC monitoring
KW - smartphone optical biosensors
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U2 - 10.3390/bios12080575
DO - 10.3390/bios12080575
M3 - Review article
C2 - 36004971
AN - SCOPUS:85136527777
SN - 2079-6374
VL - 12
JO - Biosensors
JF - Biosensors
IS - 8
M1 - 575
ER -