TY - JOUR
T1 - Cost- effectiveness of mammography screening program in a resource-limited post-soviet country of Kazakhstan
AU - Salikhanov, Islam
AU - Crape, Byron
AU - Howie, Peter
N1 - Funding Information:
We thank Alina Faizova MD. and Dinara Samenova MD., the Nur-Sultan Center of Oncology, for making available the data regarding breast cancer clinical-stage distribution, survival, and costs of treatment. We thank Alpamys Issanov MD, MPH, faculty member of the School of Medicine at the Nazarbayev University, for reviewing this paper. Ethical exempt status to conduct the research was obtained from the Nazarbayev University School of Medicine Research Ethics Committee. The research was not funded. Authors declare that they have no conflict of interest.
PY - 2019
Y1 - 2019
N2 - Objectives: To conduct cost effectiveness and benefit-cost analyses of the organized mammography-screening program in the Republic of Kazakhstan comparing women who developed breast cancer in screened and unscreened scenario. Methods: 389,352 screened women were included in the study. Among these, 895 women were further diagnosed with breast cancer. Outcomes measures include life years saved, quality-adjusted life years, incremental cost-effectiveness ratio, and value of statistical life year. Sensitivity analyses were performed to assess uncertainty.Results: Compared to no screening scenario, an organized mammography yielded an additional 1,253 life years and 790 quality-adjusted life years in 2016. The incremental cost-effectiveness ratio was equal to 3,157 USD per one QALY saved, which is two times less than the GDP per capita in Kazakhstan in 2016. Sensitivity analysis showed that the mammography remains cost-effective in the majority of the scenarios. Conclusion: Mammography screening in Kazakhstan was found to be highly cost-effective, associated with treatment cost savings, and can be an efficient use of limited resources in Kazakhstan.
AB - Objectives: To conduct cost effectiveness and benefit-cost analyses of the organized mammography-screening program in the Republic of Kazakhstan comparing women who developed breast cancer in screened and unscreened scenario. Methods: 389,352 screened women were included in the study. Among these, 895 women were further diagnosed with breast cancer. Outcomes measures include life years saved, quality-adjusted life years, incremental cost-effectiveness ratio, and value of statistical life year. Sensitivity analyses were performed to assess uncertainty.Results: Compared to no screening scenario, an organized mammography yielded an additional 1,253 life years and 790 quality-adjusted life years in 2016. The incremental cost-effectiveness ratio was equal to 3,157 USD per one QALY saved, which is two times less than the GDP per capita in Kazakhstan in 2016. Sensitivity analysis showed that the mammography remains cost-effective in the majority of the scenarios. Conclusion: Mammography screening in Kazakhstan was found to be highly cost-effective, associated with treatment cost savings, and can be an efficient use of limited resources in Kazakhstan.
KW - Benefit-cost analysis
KW - Breast cancer
KW - Cost-effectiveness analysis
KW - Mammography
KW - Screening
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U2 - 10.31557/APJCP.2019.20.10.3153
DO - 10.31557/APJCP.2019.20.10.3153
M3 - Article
AN - SCOPUS:85074426725
VL - 20
SP - 3153
EP - 3160
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
SN - 1513-7368
IS - 10
ER -