Cryo scanning probe nanotomography study of the structure of alginate microcarriers

Anton E. Efimov, Olga I. Agapova, Liubov A. Safonova, Maria M. Bobrova, Alexey D. Volkov, Laura Khamkhash, Igor I. Agapov

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Tissue-specific alginate microspheres surface modified with microparticles of decellularized liver tissue were prepared. The nanostructures of these microspheres were analysed by cryo scanning probe nanotomography. Modification of the surfaces of the alginate microspheres with microparticles of decellularized liver tissue increased surface roughness, the specific effective area, and the average autocorrelation length. Up to seven times more human hepatocellular carcinoma (HepG2) cells were adhered to the modified alginate microspheres than to the unmodified microspheres. The developed alginate microspheres can be used in regenerative medicine and tissue engineering as a biodegradable cell microcarriers.

    Original languageEnglish
    Pages (from-to)8808-8815
    Number of pages8
    JournalRSC Advances
    Volume7
    Issue number15
    DOIs
    Publication statusPublished - 2017

    ASJC Scopus subject areas

    • Chemistry(all)
    • Chemical Engineering(all)

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