Cryo scanning probe nanotomography study of the structure of alginate microcarriers

Anton E. Efimov, Olga I. Agapova, Liubov A. Safonova, Maria M. Bobrova, Alexey D. Volkov, Laura Khamkhash, Igor I. Agapov

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Tissue-specific alginate microspheres surface modified with microparticles of decellularized liver tissue were prepared. The nanostructures of these microspheres were analysed by cryo scanning probe nanotomography. Modification of the surfaces of the alginate microspheres with microparticles of decellularized liver tissue increased surface roughness, the specific effective area, and the average autocorrelation length. Up to seven times more human hepatocellular carcinoma (HepG2) cells were adhered to the modified alginate microspheres than to the unmodified microspheres. The developed alginate microspheres can be used in regenerative medicine and tissue engineering as a biodegradable cell microcarriers.

Original languageEnglish
Pages (from-to)8808-8815
Number of pages8
JournalRSC Advances
Volume7
Issue number15
DOIs
Publication statusPublished - Jan 1 2017

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Alginate
Microspheres
Scanning
Tissue
Liver
Autocorrelation
Tissue engineering
alginic acid
Nanostructures
Surface roughness

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Efimov, A. E., Agapova, O. I., Safonova, L. A., Bobrova, M. M., Volkov, A. D., Khamkhash, L., & Agapov, I. I. (2017). Cryo scanning probe nanotomography study of the structure of alginate microcarriers. RSC Advances, 7(15), 8808-8815. https://doi.org/10.1039/c6ra26516b

Cryo scanning probe nanotomography study of the structure of alginate microcarriers. / Efimov, Anton E.; Agapova, Olga I.; Safonova, Liubov A.; Bobrova, Maria M.; Volkov, Alexey D.; Khamkhash, Laura; Agapov, Igor I.

In: RSC Advances, Vol. 7, No. 15, 01.01.2017, p. 8808-8815.

Research output: Contribution to journalArticle

Efimov, AE, Agapova, OI, Safonova, LA, Bobrova, MM, Volkov, AD, Khamkhash, L & Agapov, II 2017, 'Cryo scanning probe nanotomography study of the structure of alginate microcarriers', RSC Advances, vol. 7, no. 15, pp. 8808-8815. https://doi.org/10.1039/c6ra26516b
Efimov AE, Agapova OI, Safonova LA, Bobrova MM, Volkov AD, Khamkhash L et al. Cryo scanning probe nanotomography study of the structure of alginate microcarriers. RSC Advances. 2017 Jan 1;7(15):8808-8815. https://doi.org/10.1039/c6ra26516b
Efimov, Anton E. ; Agapova, Olga I. ; Safonova, Liubov A. ; Bobrova, Maria M. ; Volkov, Alexey D. ; Khamkhash, Laura ; Agapov, Igor I. / Cryo scanning probe nanotomography study of the structure of alginate microcarriers. In: RSC Advances. 2017 ; Vol. 7, No. 15. pp. 8808-8815.
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