Cutting edge

IgE plays an active role in tumor immunosurveillance in mice

Elisa A. Nigro, Anna T. Brini, Vijay A. Yenagi, Lorena M. Ferreira, Gertrude Achatz-Straussberger, Alessandro Ambrosi, Francesca Sanvito, Elisa Soprana, Eelco Van Anken, Gernot Achatz, Antonio G. Siccardi, Luca Vangelista

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Exogenous IgE acts as an adjuvant in tumor vaccination in mice, and therefore a direct role of endogenous IgE in tumor immunosurveillance was investigated. By using genetically engineered mice, we found that IgE ablation rendered mice more susceptible to the growth of transplantable tumors. Conversely, a strengthened IgE response provided mice with partial or complete resistance to tumor growth, depending on the tumor type. By genetic crosses, we showed that IgE-mediated tumor protection was mostly lost in mice lacking FceRI. Tumor protection was also lost after depletion of CD8+ T cells, highlighting a cross-Talk between IgE and T cell- mediated tumor immunosurveillance. Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for clinical oncology. The Journal of Immunology, 2016, 197: 2583-2588.

Original languageEnglish
Pages (from-to)2583-2588
Number of pages6
JournalJournal of Immunology
Volume197
Issue number7
DOIs
Publication statusPublished - Oct 1 2016

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Immunologic Monitoring
Immunoglobulin E
Neoplasms
Genetic Crosses
T-Lymphocytes
Medical Oncology
Growth
Allergy and Immunology
Vaccination

ASJC Scopus subject areas

  • Immunology

Cite this

Nigro, E. A., Brini, A. T., Yenagi, V. A., Ferreira, L. M., Achatz-Straussberger, G., Ambrosi, A., ... Vangelista, L. (2016). Cutting edge: IgE plays an active role in tumor immunosurveillance in mice. Journal of Immunology, 197(7), 2583-2588. https://doi.org/10.4049/jimmunol.1601026

Cutting edge : IgE plays an active role in tumor immunosurveillance in mice. / Nigro, Elisa A.; Brini, Anna T.; Yenagi, Vijay A.; Ferreira, Lorena M.; Achatz-Straussberger, Gertrude; Ambrosi, Alessandro; Sanvito, Francesca; Soprana, Elisa; Van Anken, Eelco; Achatz, Gernot; Siccardi, Antonio G.; Vangelista, Luca.

In: Journal of Immunology, Vol. 197, No. 7, 01.10.2016, p. 2583-2588.

Research output: Contribution to journalArticle

Nigro, EA, Brini, AT, Yenagi, VA, Ferreira, LM, Achatz-Straussberger, G, Ambrosi, A, Sanvito, F, Soprana, E, Van Anken, E, Achatz, G, Siccardi, AG & Vangelista, L 2016, 'Cutting edge: IgE plays an active role in tumor immunosurveillance in mice', Journal of Immunology, vol. 197, no. 7, pp. 2583-2588. https://doi.org/10.4049/jimmunol.1601026
Nigro EA, Brini AT, Yenagi VA, Ferreira LM, Achatz-Straussberger G, Ambrosi A et al. Cutting edge: IgE plays an active role in tumor immunosurveillance in mice. Journal of Immunology. 2016 Oct 1;197(7):2583-2588. https://doi.org/10.4049/jimmunol.1601026
Nigro, Elisa A. ; Brini, Anna T. ; Yenagi, Vijay A. ; Ferreira, Lorena M. ; Achatz-Straussberger, Gertrude ; Ambrosi, Alessandro ; Sanvito, Francesca ; Soprana, Elisa ; Van Anken, Eelco ; Achatz, Gernot ; Siccardi, Antonio G. ; Vangelista, Luca. / Cutting edge : IgE plays an active role in tumor immunosurveillance in mice. In: Journal of Immunology. 2016 ; Vol. 197, No. 7. pp. 2583-2588.
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