Cutting edge: IgE plays an active role in tumor immunosurveillance in mice

Elisa A. Nigro, Anna T. Brini, Vijay A. Yenagi, Lorena M. Ferreira, Gertrude Achatz-Straussberger, Alessandro Ambrosi, Francesca Sanvito, Elisa Soprana, Eelco Van Anken, Gernot Achatz, Antonio G. Siccardi, Luca Vangelista

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Exogenous IgE acts as an adjuvant in tumor vaccination in mice, and therefore a direct role of endogenous IgE in tumor immunosurveillance was investigated. By using genetically engineered mice, we found that IgE ablation rendered mice more susceptible to the growth of transplantable tumors. Conversely, a strengthened IgE response provided mice with partial or complete resistance to tumor growth, depending on the tumor type. By genetic crosses, we showed that IgE-mediated tumor protection was mostly lost in mice lacking FceRI. Tumor protection was also lost after depletion of CD8+ T cells, highlighting a cross-Talk between IgE and T cell- mediated tumor immunosurveillance. Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for clinical oncology. The Journal of Immunology, 2016, 197: 2583-2588.

Original languageEnglish
Pages (from-to)2583-2588
Number of pages6
JournalJournal of Immunology
Volume197
Issue number7
DOIs
Publication statusPublished - Oct 1 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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