Abstract
The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
| Original language | English |
|---|---|
| Pages (from-to) | 334-338 |
| Number of pages | 5 |
| Journal | Trends in Biochemical Sciences |
| Volume | 18 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Cyclosporin A, FK506 and rapamycin : more than just immunosuppression. / Kunz, Jeannette; Hall, Michael N.
In: Trends in Biochemical Sciences, Vol. 18, No. 9, 1993, p. 334-338.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cyclosporin A, FK506 and rapamycin
T2 - more than just immunosuppression
AU - Kunz, Jeannette
AU - Hall, Michael N.
PY - 1993
Y1 - 1993
N2 - The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
AB - The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
UR - http://www.scopus.com/inward/record.url?scp=0027274978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027274978&partnerID=8YFLogxK
U2 - 10.1016/0968-0004(93)90069-Y
DO - 10.1016/0968-0004(93)90069-Y
M3 - Article
C2 - 7694398
AN - SCOPUS:0027274978
VL - 18
SP - 334
EP - 338
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0376-5067
IS - 9
ER -