Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

Jeannette Kunz, Michael N. Hall

Research output: Contribution to journalReview articlepeer-review

239 Citations (Scopus)


The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.

Original languageEnglish
Pages (from-to)334-338
Number of pages5
JournalTrends in Biochemical Sciences
Issue number9
Publication statusPublished - Sep 1993

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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