Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

Jeannette Kunz; Michael N. Hall

doi:10.1016/0968-0004(93)90069-Y

Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

Jeannette Kunz, Michael N. Hall

Department of Biology

Research output: Contribution to journal › Review article › peer-review

238 Citations (Scopus)

Abstract

The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.

Original language	English
Pages (from-to)	334-338
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	18
Issue number	9
DOIs	https://doi.org/10.1016/0968-0004(93)90069-Y
Publication status	Published - Sep 1993

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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abstract = "The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.",

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