Cyclosporin A, FK506 and rapamycin

more than just immunosuppression

Jeannette Kunz, Michael N. Hall

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophillin and FK506-FKBP complexes, and reveal a phospatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.

Original languageEnglish
Pages (from-to)334-338
Number of pages5
JournalTrends in Biochemical Sciences
Volume18
Issue number9
DOIs
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Tacrolimus Binding Proteins
Tacrolimus
Sirolimus
Yeast
Immunosuppression
Cyclosporine
Yeasts
T-cells
Calcineurin
Immunosuppressive Agents
Phosphotransferases
T-Lymphocytes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry

Cite this

Cyclosporin A, FK506 and rapamycin : more than just immunosuppression. / Kunz, Jeannette; Hall, Michael N.

In: Trends in Biochemical Sciences, Vol. 18, No. 9, 1993, p. 334-338.

Research output: Contribution to journalArticle

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