CysView: Protein classification based on cysteine pairing patterns

Johann Lenffer, Paulo Lai, Wafaa El Mejaber, Asif M. Khan, Judice L.Y. Koh, Paul T.J. Tan, Seng H. Seah, Vladimir Brusic

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

CysView is a web-based application tool that identifies and classifies proteins according to their disulfide connectivity patterns. It accepts a dataset of annotated protein sequences in various formats and returns a graphical representation of cysteine pairing patterns. CysView displays cysteine patterns for those records in the data with disulfide annotations. It allows the viewing of records grouped by connectivity patterns. CysView's utility as an analysis tool was demonstrated by the rapid and correct classification of scorpion toxin entries from GenPept on the basis of their disulfide pairing patterns. It has proved useful for rapid detection of irrelevant and partial records, or those with incomplete annotations. CysView can be used to support distant homology between proteins. CysView is publicly available at http://research.i2r.a-star.edu.sg/CysView/.

Original languageEnglish
Pages (from-to)W350-W355
JournalNucleic Acids Research
Volume32
Issue numberWEB SERVER ISS.
DOIs
Publication statusPublished - Jul 1 2004

ASJC Scopus subject areas

  • Genetics

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    Lenffer, J., Lai, P., El Mejaber, W., Khan, A. M., Koh, J. L. Y., Tan, P. T. J., Seah, S. H., & Brusic, V. (2004). CysView: Protein classification based on cysteine pairing patterns. Nucleic Acids Research, 32(WEB SERVER ISS.), W350-W355. https://doi.org/10.1093/nar/gkh475