Cytoskeletal network in colon cancer: From genes to clinical application

Andrea Buda, Massimo Pignatelli

Research output: Contribution to journalShort survey

48 Citations (Scopus)

Abstract

Colorectal cancer arises from well-defined sequential steps characterised by distinct genetic events. Abnormalities in the expression and functional activity of cell adhesion molecules are implicated in the development and progression of the majority of colorectal cancers. Intercellular (e.g. E-cadherin/catenin complex) and cell-matrix (e.g. integrins) adhesion molecules are more than just cementing substances but regulate cell polarity, differentiation, proliferation, migration and invasion. Many of these cellular events are mediated through their intimate association with the actin cytoskeletal network. A dynamic actin cytoskeleton characterises normal epithelial cells and polymerisation and depolymerisation of actin filaments enables cell shape to change during migration and mitosis. In colorectal cancer, cells lose actin cytoskeletal organisation and normal cell adhesion when they become invasive. Future investigations should allow the unravelling of new cytoskeletal network functions in tumour biology and may lead to the development of novel therapeutic strategies based on the manipulation of its associated molecules.

Original languageEnglish
Pages (from-to)759-765
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
Volume36
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Actin
  • Adhesion molecules
  • Bowel cancer

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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