Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis. Evidence that antibody modulation may cause protracted infection

Massimo Pignatelli, Jenny Waters, Andrew Lever, Sten Iwarson, Robert Gerety, Howard C. Thomas

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The nucleocapsid antigens (HBc and HBe) are present on the membranes of HBV-infected hepatocytes from HBV carriers. In autologous cytotoxicity experiments we demonstrate that cytotoxic T cells sensitised to the nucleocapsid proteins of hepatitis B are present in HBe antigen-positive HBV carriers with chronic hepatitis and can be blocked by monoclonal anti-HBc and anti-HBe. Passive immunisation of chimpanzees with monoclonal anti-HBc and anti-HBe offers no protection against HBV infection but in both cases leads to an unusually prolonged hepatitis probably by modulation of HBc and HBe antigen display on the hepatocytes. High-titre anti-HBc in the circulation of HBe antigen-positive patients probably modulates the former protein making HBe the important target antigen for cytotoxic T cells mediating liver damage in chronic carriers. These data also support the hypothesis that passive transfer of IgG anti-HBc across the placenta may be one major factor promoting development of persistent infection in neonates infected from carrier mothers.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalJournal of Hepatology
Volume4
Issue number1
DOIs
Publication statusPublished - 1987
Externally publishedYes

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Nucleocapsid Proteins
Chronic Hepatitis
T-Lymphocytes
Antigens
Antibodies
Infection
Hepatocytes
Nucleocapsid
Passive Immunization
Pan troglodytes
Hepatitis B
Placenta
Hepatitis
Mothers
Newborn Infant
Membranes
Liver
Proteins

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis. Evidence that antibody modulation may cause protracted infection. / Pignatelli, Massimo; Waters, Jenny; Lever, Andrew; Iwarson, Sten; Gerety, Robert; Thomas, Howard C.

In: Journal of Hepatology, Vol. 4, No. 1, 1987, p. 15-21.

Research output: Contribution to journalArticle

Pignatelli, Massimo ; Waters, Jenny ; Lever, Andrew ; Iwarson, Sten ; Gerety, Robert ; Thomas, Howard C. / Cytotoxic T-cell responses to the nucleocapsid proteins of HBV in chronic hepatitis. Evidence that antibody modulation may cause protracted infection. In: Journal of Hepatology. 1987 ; Vol. 4, No. 1. pp. 15-21.
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