Abstract
Increased demand of environment protection encouraged scientists to design products and processes that minimize the use and generation of hazardous substances. This work presents comprehensive result of large-scale fabrication and investigation of red-to-green tunable submicron spherical yttria particles codoped with low concentrations of Eu+3 and Tb+3. The color emission of synthesized particles can be precisely tuned from red to green by simple variation of Tb/Eu ratio and excitation wavelength. The Tb/Eu-codoped Y2O3 particles did not adversely affect the viability of L-929 fibroblastic cells at concentrations less than 62.5 ppm. Through internalization and wide distribution inside the cells, Tb/Eu codoped Y 2O3 particles with intense bright green or red fluorescence rendered cell imaging to be possible. The high brightness, excellent stability, low-toxicity, and imaging capability along with fine color-tunability of synthesized particles enable to find promising application in various areas.
| Original language | English |
|---|---|
| Pages (from-to) | 2287-2294 |
| Number of pages | 8 |
| Journal | Journal of Biomedical Materials Research - Part A |
| Volume | 100 A |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2012 |
| Externally published | Yes |
Fingerprint
Keywords
- cell imaging
- cytotoxicity
- doping
- luminescence
- YO particles
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Ceramics and Composites
- Metals and Alloys
Cite this
Cytotoxicity and cell imaging potentials of submicron color-tunable yttria particles. / Atabaev, Timur Sh; Lee, Jong Ho; Han, Dong Wook; Hwang, Yoon Hwae; Kim, Hyung Kook.
In: Journal of Biomedical Materials Research - Part A, Vol. 100 A, No. 9, 09.2012, p. 2287-2294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytotoxicity and cell imaging potentials of submicron color-tunable yttria particles
AU - Atabaev, Timur Sh
AU - Lee, Jong Ho
AU - Han, Dong Wook
AU - Hwang, Yoon Hwae
AU - Kim, Hyung Kook
PY - 2012/9
Y1 - 2012/9
N2 - Increased demand of environment protection encouraged scientists to design products and processes that minimize the use and generation of hazardous substances. This work presents comprehensive result of large-scale fabrication and investigation of red-to-green tunable submicron spherical yttria particles codoped with low concentrations of Eu+3 and Tb+3. The color emission of synthesized particles can be precisely tuned from red to green by simple variation of Tb/Eu ratio and excitation wavelength. The Tb/Eu-codoped Y2O3 particles did not adversely affect the viability of L-929 fibroblastic cells at concentrations less than 62.5 ppm. Through internalization and wide distribution inside the cells, Tb/Eu codoped Y 2O3 particles with intense bright green or red fluorescence rendered cell imaging to be possible. The high brightness, excellent stability, low-toxicity, and imaging capability along with fine color-tunability of synthesized particles enable to find promising application in various areas.
AB - Increased demand of environment protection encouraged scientists to design products and processes that minimize the use and generation of hazardous substances. This work presents comprehensive result of large-scale fabrication and investigation of red-to-green tunable submicron spherical yttria particles codoped with low concentrations of Eu+3 and Tb+3. The color emission of synthesized particles can be precisely tuned from red to green by simple variation of Tb/Eu ratio and excitation wavelength. The Tb/Eu-codoped Y2O3 particles did not adversely affect the viability of L-929 fibroblastic cells at concentrations less than 62.5 ppm. Through internalization and wide distribution inside the cells, Tb/Eu codoped Y 2O3 particles with intense bright green or red fluorescence rendered cell imaging to be possible. The high brightness, excellent stability, low-toxicity, and imaging capability along with fine color-tunability of synthesized particles enable to find promising application in various areas.
KW - cell imaging
KW - cytotoxicity
KW - doping
KW - luminescence
KW - YO particles
UR - http://www.scopus.com/inward/record.url?scp=84864411949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864411949&partnerID=8YFLogxK
U2 - 10.1002/jbm.a.34168
DO - 10.1002/jbm.a.34168
M3 - Article
VL - 100 A
SP - 2287
EP - 2294
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
SN - 1549-3296
IS - 9
ER -