Cytotoxicity and cell imaging potentials of submicron color-tunable yttria particles

Timur Sh Atabaev, Jong Ho Lee, Dong Wook Han, Yoon Hwae Hwang, Hyung Kook Kim

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Increased demand of environment protection encouraged scientists to design products and processes that minimize the use and generation of hazardous substances. This work presents comprehensive result of large-scale fabrication and investigation of red-to-green tunable submicron spherical yttria particles codoped with low concentrations of Eu+3 and Tb+3. The color emission of synthesized particles can be precisely tuned from red to green by simple variation of Tb/Eu ratio and excitation wavelength. The Tb/Eu-codoped Y2O3 particles did not adversely affect the viability of L-929 fibroblastic cells at concentrations less than 62.5 ppm. Through internalization and wide distribution inside the cells, Tb/Eu codoped Y 2O3 particles with intense bright green or red fluorescence rendered cell imaging to be possible. The high brightness, excellent stability, low-toxicity, and imaging capability along with fine color-tunability of synthesized particles enable to find promising application in various areas.

Original languageEnglish
Pages (from-to)2287-2294
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume100 A
Issue number9
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

Keywords

  • cell imaging
  • cytotoxicity
  • doping
  • luminescence
  • YO particles

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys

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