Abstract
Functional compartmentalization of dendrites is thought to underlie afferent-specific integration of neural activity in laminar brain structures. Here we show that in the lateral nucleus of the amygdala (LA), an area lacking apparent laminar organization, thalamic and cortical afferents converge on the same dendrites, contacting neighboring but morphologically and functionally distinct spine types. Large spines contacted by thalamic afferents exhibited larger Ca2+ transients during action potential backpropagation than did small spines contacted by cortical afferents. Accordingly, induction of Hebbian plasticity, dependent on postsynaptic spikes, was restricted to thalamic afferents. This synapse-specific effect involved activation of R-type voltage-dependent Ca2+ channels preferentially located at thalamic inputs. These results indicate that afferent-specific mechanisms of postsynaptic, associative Hebbian plasticity in LA projection neurons depend on local, spine-specific morphological and molecular properties, rather than global differences between dendritic compartments.
| Original language | English |
|---|---|
| Pages (from-to) | 119-131 |
| Number of pages | 13 |
| Journal | Neuron |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 6 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Dendritic spine heterogeneity determines afferent-specific Hebbian plasticity in the amygdala. / Humeau, Yann; Herry, Cyril; Kemp, Nicola; Shaban, Hamdy; Fourcaudot, Elodie; Bissière, Stephanie; Lüthi, Andreas.
In: Neuron, Vol. 45, No. 1, 06.01.2005, p. 119-131.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dendritic spine heterogeneity determines afferent-specific Hebbian plasticity in the amygdala
AU - Humeau, Yann
AU - Herry, Cyril
AU - Kemp, Nicola
AU - Shaban, Hamdy
AU - Fourcaudot, Elodie
AU - Bissière, Stephanie
AU - Lüthi, Andreas
PY - 2005/1/6
Y1 - 2005/1/6
N2 - Functional compartmentalization of dendrites is thought to underlie afferent-specific integration of neural activity in laminar brain structures. Here we show that in the lateral nucleus of the amygdala (LA), an area lacking apparent laminar organization, thalamic and cortical afferents converge on the same dendrites, contacting neighboring but morphologically and functionally distinct spine types. Large spines contacted by thalamic afferents exhibited larger Ca2+ transients during action potential backpropagation than did small spines contacted by cortical afferents. Accordingly, induction of Hebbian plasticity, dependent on postsynaptic spikes, was restricted to thalamic afferents. This synapse-specific effect involved activation of R-type voltage-dependent Ca2+ channels preferentially located at thalamic inputs. These results indicate that afferent-specific mechanisms of postsynaptic, associative Hebbian plasticity in LA projection neurons depend on local, spine-specific morphological and molecular properties, rather than global differences between dendritic compartments.
AB - Functional compartmentalization of dendrites is thought to underlie afferent-specific integration of neural activity in laminar brain structures. Here we show that in the lateral nucleus of the amygdala (LA), an area lacking apparent laminar organization, thalamic and cortical afferents converge on the same dendrites, contacting neighboring but morphologically and functionally distinct spine types. Large spines contacted by thalamic afferents exhibited larger Ca2+ transients during action potential backpropagation than did small spines contacted by cortical afferents. Accordingly, induction of Hebbian plasticity, dependent on postsynaptic spikes, was restricted to thalamic afferents. This synapse-specific effect involved activation of R-type voltage-dependent Ca2+ channels preferentially located at thalamic inputs. These results indicate that afferent-specific mechanisms of postsynaptic, associative Hebbian plasticity in LA projection neurons depend on local, spine-specific morphological and molecular properties, rather than global differences between dendritic compartments.
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U2 - 10.1016/j.neuron.2004.12.019
DO - 10.1016/j.neuron.2004.12.019
M3 - Article
VL - 45
SP - 119
EP - 131
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 1
ER -