Isobutyl acrylate (i-BA) can be produced by direct esterification of acrylic acid with isobutanol using solid-based catalysts. The novelty of this work consists in developing a process for i-BA production, for which design, control and economic evaluation studies have not been reported in literature. The reaction is performed in a multitubular fixed-bed reactor, while the separation system employs conventional distillation equipment. The difficult separation between the acrylate and acid (close boiling and maximum temperature homogeneous azeotropy at 1.013 bar) is achieved by vacuum distillation, condition at which the relative volatility increases and the azeotrope disappears. The process is controllable, the control system showing robustness when production capacity and reactor temperature change. The economic evaluation shows attractive key economic indicators in terms of revenues, and capital and utility costs.