Design of multi-layer coated particles with sigmoidal release pattern

Ryusei Ito, Boris Golman, Kunio Shinohara

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In order to design and control the release pattern of an active solid component, we investigated the release characteristics of core particles coated with multiple layers of fine permeable particles surrounding soluble particles dispersed in layers of impermeable wax. We examined the effect of operational conditions on the parameters of the release profile by multivariate analysis, and obtained simplified correlations for the maximum release rate and the lag time of the release curve as a function of the volume fraction of permeable particles and the thickness of the permeable- and soluble-particle layers. The results confirmed that the desired release rate could be obtained in the first place by adjusting the volume fraction and the thickness of the permeable-particle layer, while it was also possible to attain the required lag time by changing the thickness of the soluble layer. Finally, the calculation examples successfully illustrated the possibility of our being able to design the controlled-release particles with a prescribed sigmoidal release.

Original languageEnglish
Pages (from-to)5415-5424
Number of pages10
JournalChemical Engineering Science
Volume60
Issue number20
DOIs
Publication statusPublished - Oct 2005
Externally publishedYes

Fingerprint

Volume fraction
Waxes
Multivariate Analysis

Keywords

  • Controlled release
  • Modeling
  • Particle processing
  • Product design
  • Sigmoidal release pattern

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Design of multi-layer coated particles with sigmoidal release pattern. / Ito, Ryusei; Golman, Boris; Shinohara, Kunio.

In: Chemical Engineering Science, Vol. 60, No. 20, 10.2005, p. 5415-5424.

Research output: Contribution to journalArticle

Ito, Ryusei ; Golman, Boris ; Shinohara, Kunio. / Design of multi-layer coated particles with sigmoidal release pattern. In: Chemical Engineering Science. 2005 ; Vol. 60, No. 20. pp. 5415-5424.
@article{b96596a932fc4220b556ebb2bb7f2b6e,
title = "Design of multi-layer coated particles with sigmoidal release pattern",
abstract = "In order to design and control the release pattern of an active solid component, we investigated the release characteristics of core particles coated with multiple layers of fine permeable particles surrounding soluble particles dispersed in layers of impermeable wax. We examined the effect of operational conditions on the parameters of the release profile by multivariate analysis, and obtained simplified correlations for the maximum release rate and the lag time of the release curve as a function of the volume fraction of permeable particles and the thickness of the permeable- and soluble-particle layers. The results confirmed that the desired release rate could be obtained in the first place by adjusting the volume fraction and the thickness of the permeable-particle layer, while it was also possible to attain the required lag time by changing the thickness of the soluble layer. Finally, the calculation examples successfully illustrated the possibility of our being able to design the controlled-release particles with a prescribed sigmoidal release.",
keywords = "Controlled release, Modeling, Particle processing, Product design, Sigmoidal release pattern",
author = "Ryusei Ito and Boris Golman and Kunio Shinohara",
year = "2005",
month = "10",
doi = "10.1016/j.ces.2005.04.023",
language = "English",
volume = "60",
pages = "5415--5424",
journal = "Chemical Engineering Science",
issn = "0009-2509",
publisher = "Elsevier",
number = "20",

}

TY - JOUR

T1 - Design of multi-layer coated particles with sigmoidal release pattern

AU - Ito, Ryusei

AU - Golman, Boris

AU - Shinohara, Kunio

PY - 2005/10

Y1 - 2005/10

N2 - In order to design and control the release pattern of an active solid component, we investigated the release characteristics of core particles coated with multiple layers of fine permeable particles surrounding soluble particles dispersed in layers of impermeable wax. We examined the effect of operational conditions on the parameters of the release profile by multivariate analysis, and obtained simplified correlations for the maximum release rate and the lag time of the release curve as a function of the volume fraction of permeable particles and the thickness of the permeable- and soluble-particle layers. The results confirmed that the desired release rate could be obtained in the first place by adjusting the volume fraction and the thickness of the permeable-particle layer, while it was also possible to attain the required lag time by changing the thickness of the soluble layer. Finally, the calculation examples successfully illustrated the possibility of our being able to design the controlled-release particles with a prescribed sigmoidal release.

AB - In order to design and control the release pattern of an active solid component, we investigated the release characteristics of core particles coated with multiple layers of fine permeable particles surrounding soluble particles dispersed in layers of impermeable wax. We examined the effect of operational conditions on the parameters of the release profile by multivariate analysis, and obtained simplified correlations for the maximum release rate and the lag time of the release curve as a function of the volume fraction of permeable particles and the thickness of the permeable- and soluble-particle layers. The results confirmed that the desired release rate could be obtained in the first place by adjusting the volume fraction and the thickness of the permeable-particle layer, while it was also possible to attain the required lag time by changing the thickness of the soluble layer. Finally, the calculation examples successfully illustrated the possibility of our being able to design the controlled-release particles with a prescribed sigmoidal release.

KW - Controlled release

KW - Modeling

KW - Particle processing

KW - Product design

KW - Sigmoidal release pattern

UR - http://www.scopus.com/inward/record.url?scp=22244466743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22244466743&partnerID=8YFLogxK

U2 - 10.1016/j.ces.2005.04.023

DO - 10.1016/j.ces.2005.04.023

M3 - Article

AN - SCOPUS:22244466743

VL - 60

SP - 5415

EP - 5424

JO - Chemical Engineering Science

JF - Chemical Engineering Science

SN - 0009-2509

IS - 20

ER -