Design of multi-layer coated particles with sigmoidal release pattern

Ryusei Ito, Boris Golman, Kunio Shinohara

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


In order to design and control the release pattern of an active solid component, we investigated the release characteristics of core particles coated with multiple layers of fine permeable particles surrounding soluble particles dispersed in layers of impermeable wax. We examined the effect of operational conditions on the parameters of the release profile by multivariate analysis, and obtained simplified correlations for the maximum release rate and the lag time of the release curve as a function of the volume fraction of permeable particles and the thickness of the permeable- and soluble-particle layers. The results confirmed that the desired release rate could be obtained in the first place by adjusting the volume fraction and the thickness of the permeable-particle layer, while it was also possible to attain the required lag time by changing the thickness of the soluble layer. Finally, the calculation examples successfully illustrated the possibility of our being able to design the controlled-release particles with a prescribed sigmoidal release.

Original languageEnglish
Pages (from-to)5415-5424
Number of pages10
JournalChemical Engineering Science
Issue number20
Publication statusPublished - Oct 2005


  • Controlled release
  • Modeling
  • Particle processing
  • Product design
  • Sigmoidal release pattern

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

Fingerprint Dive into the research topics of 'Design of multi-layer coated particles with sigmoidal release pattern'. Together they form a unique fingerprint.

Cite this