Abstract
The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.
| Original language | English |
|---|---|
| Pages (from-to) | 253-265 |
| Number of pages | 13 |
| Journal | Mechanisms of Development |
| Volume | 109 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Developmental Biology
- Developmental Neuroscience
Cite this
Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10. / Sonnenberg-Riethmacher, Eva; Miehe, Michaela; Stolt, Claus C.; Goerich, Derk E.; Wegner, Michael; Riethmacher, Dieter.
In: Mechanisms of Development, Vol. 109, No. 2, 2001, p. 253-265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10
AU - Sonnenberg-Riethmacher, Eva
AU - Miehe, Michaela
AU - Stolt, Claus C.
AU - Goerich, Derk E.
AU - Wegner, Michael
AU - Riethmacher, Dieter
PY - 2001
Y1 - 2001
N2 - The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.
AB - The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035204526&partnerID=8YFLogxK
U2 - 10.1016/S0925-4773(01)00547-0
DO - 10.1016/S0925-4773(01)00547-0
M3 - Article
VL - 109
SP - 253
EP - 265
JO - Mechanisms of Development
JF - Mechanisms of Development
SN - 0925-4773
IS - 2
ER -