Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10

Eva Sonnenberg-Riethmacher, Michaela Miehe, Claus C. Stolt, Derk E. Goerich, Michael Wegner, Dieter Riethmacher

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The HMG-domain transcription factor Sox10 is essential for the development of various neural crest derived lineages including glia and neurons of the peripheral nervous system (PNS). Within the PNS the most striking defect is the complete absence of glial differentiation whereas neurogenesis seemed initially normal. A degeneration of motoneurons and sensory neurons occurred later in development. The mechanism that leads to the dramatic effects on the neural crest derived cell lineages in the dorsal root ganglia (DRG), however, has not been examined up to now. Here, we provide a detailed analysis of proliferation and apoptosis in the DRG during the time of their generation and lineage segregation (between E 9.5 and E 11.5). We show that both increased apoptosis as well as decreased proliferation of neural crest cells contribute to the observed hypomorphism.

Original languageEnglish
Pages (from-to)253-265
Number of pages13
JournalMechanisms of Development
Volume109
Issue number2
DOIs
Publication statusPublished - Jan 1 2001

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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