TY - GEN
T1 - Development of a microfluidic device and nanofiber membranes for emulating air-blood barrier in lung-on-a-chip devices
AU - Kanabekova, Perizat
AU - Dauletkanov, Bereke
AU - Kadyrova, Adina
AU - Akhmetova, Alma
AU - Kulsharova, Gulsim
N1 - Funding Information:
*Research supported by Nazarbayev University Faculty-development research grant (080420FD1910), the Ministry of Education and Science of the Republic of Kazakhstan Grant for young scientists (AP09058308).
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Here, we present the development of the first prototype of a microfluidic chip with two compartments and a nanofiber membrane for mimicking the air-blood barrier toward integration of the membrane into the device for use in lung-on-a-chip applications. A microfluidic device with two microchannels for air and cell culture media compartments was developed. Thin film and nanofiber membranes have been developed and fabricated for comparison with standard material reported for lung-on-a-chip devices. In this paper, we present preliminary results on the design of the microfluidic chip, the development of thin-film membranes, and electrospun nanofiber membranes. Nanofiber membranes made of polycaprolactone and microcrystalline cellulose (PCL: MCC) and other polymers were analysed and tested on cell growth, the absorbance of small molecules, and mechanical properties. An optimal nanofiber membrane has the potential of being integrated and tested in fluidic conditions to mimic the natural structure air-blood barrier present in the lung alveoli in vitro.
AB - Here, we present the development of the first prototype of a microfluidic chip with two compartments and a nanofiber membrane for mimicking the air-blood barrier toward integration of the membrane into the device for use in lung-on-a-chip applications. A microfluidic device with two microchannels for air and cell culture media compartments was developed. Thin film and nanofiber membranes have been developed and fabricated for comparison with standard material reported for lung-on-a-chip devices. In this paper, we present preliminary results on the design of the microfluidic chip, the development of thin-film membranes, and electrospun nanofiber membranes. Nanofiber membranes made of polycaprolactone and microcrystalline cellulose (PCL: MCC) and other polymers were analysed and tested on cell growth, the absorbance of small molecules, and mechanical properties. An optimal nanofiber membrane has the potential of being integrated and tested in fluidic conditions to mimic the natural structure air-blood barrier present in the lung alveoli in vitro.
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U2 - 10.1109/NEMS54180.2022.9791186
DO - 10.1109/NEMS54180.2022.9791186
M3 - Conference contribution
AN - SCOPUS:85133480012
T3 - 17th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2022
SP - 124
EP - 128
BT - 17th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2022
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 17th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2022
Y2 - 14 April 2022 through 17 April 2022
ER -