Development of a microfluidic device and nanofiber membranes for emulating air-blood barrier in lung-on-a-chip devices

Perizat Kanabekova, Bereke Dauletkanov, Adina Kadyrova, Alma Akhmetova, Gulsim Kulsharova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here, we present the development of the first prototype of a microfluidic chip with two compartments and a nanofiber membrane for mimicking the air-blood barrier toward integration of the membrane into the device for use in lung-on-a-chip applications. A microfluidic device with two microchannels for air and cell culture media compartments was developed. Thin film and nanofiber membranes have been developed and fabricated for comparison with standard material reported for lung-on-a-chip devices. In this paper, we present preliminary results on the design of the microfluidic chip, the development of thin-film membranes, and electrospun nanofiber membranes. Nanofiber membranes made of polycaprolactone and microcrystalline cellulose (PCL: MCC) and other polymers were analysed and tested on cell growth, the absorbance of small molecules, and mechanical properties. An optimal nanofiber membrane has the potential of being integrated and tested in fluidic conditions to mimic the natural structure air-blood barrier present in the lung alveoli in vitro.

Original languageEnglish
Title of host publication17th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2022
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages124-128
Number of pages5
ISBN (Electronic)9781665483018
DOIs
Publication statusPublished - 2022
Event17th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2022 - Virtual, Online, Taiwan
Duration: Apr 14 2022Apr 17 2022

Publication series

Name17th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2022

Conference

Conference17th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2022
Country/TerritoryTaiwan
CityVirtual, Online
Period4/14/224/17/22

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Instrumentation

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