Diagnostic value of serum tumor markers for adnexal masses

Milan Terzic, Jelena Dotlic, Ivana Likic, Branka Nikolic, Natasa Brndusic, Igor Pilic, Jovan Bila, Sanja Maricic, Nebojsa Arsenovic

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objective: The study aim was to investigate the diagnostic value of measuring preoperative serum tumor markers in patients with adnexal masses. Methods: The study included all (358) consecutive patients treated for adnexal tumors at the Clinic of Obstetrics and Gynecology, Clinical Center of Serbia during 12 months. Tumor-marker levels (Ca 125, CEA, HE 4, Ca 19.9 and Ca 15.3) obtained from all women on admission were compared with histopathological findings in cases in which tumors were removed. Results: Women with malignant tumors had the highest levels of Ca 125, CEA and HE 4 (p<0.01). Mucinous adenocarcinoma produced the highest amounts of Ca 19.9 and CEA. Ca 15.3 was the highest in women with endometrioid carcinoma. There were no significant differences in the levels of all serum tumor markers between women with benign and borderline tumors (p>0.05). Malignant forms of tumors were well indicated by Ca 125, HE 4 and Ca 15.3 levels. The combination of Ca 125 and HE 4 resulted in the highest sensitivity, specificity, and positive or negative predictive value (91.04%, 87.6%, 67.9%, 77.2%, respectively). Conclusions: Blood levels of tumor markers can be effective? predictors of the nature of adnexal masses. For the most precise evaluation, a combination of serum tumor markers should be used.

Original languageEnglish
Pages (from-to)417-423
Number of pages7
JournalCentral European Journal of Medicine
Issue number3
Publication statusPublished - Jan 1 2014


  • Adnexal masses
  • Preoperative evaluation
  • Tumor markers

ASJC Scopus subject areas

  • Medicine(all)

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