Diazepam inhibits cell respiration and induces fragmentation of mitochondrial reticulum

Ivan A. Vorobjev, Dmitry B. Zorov

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Diazepam (70-150 μg/ml) significantly inhibits oxygen consumption by pig kidney embryo cells and causes the cellular ATP level to fall. The maximum inhibitory effect develops after 1.5-2.5 h of diazepam treatment. In isolated mitochondria diazepam inhibits respiration in state 2 and 3u with glutamate and in state 3u with succinate. Ethylrhodamine staining and electron microscopic study reveal fragmentation of mitochondria in living cells.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalFEBS Letters
Volume163
Issue number2
DOIs
Publication statusPublished - Nov 14 1983

Keywords

  • Cell culture
  • Diazepam
  • Fluorescent probe
  • Membrane potential
  • Mitochondrial reticulum
  • Respiration

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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