Direct addition of 2-methylazines to aryl glyoxals for the synthesis of α-hydroxy ketones

Binbin Li, Huiping Wei, Haiyan Li, Olga P. Pereshivko, Vsevolod A. Peshkov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A catalyst-free protocol for the reaction of 2-methylazines and aryl glyoxal hydrates leading to α-hydroxy ketones bearing azaarene moiety is described. The process is operationally simple and can be applied to a broad range of substrates.

Original languageEnglish
Pages (from-to)5231-5234
Number of pages4
JournalTetrahedron Letters
Volume56
Issue number37
DOIs
Publication statusPublished - Aug 11 2015
Externally publishedYes

Keywords

  • 2-Methylazines
  • Aryl glyoxals
  • Azaarenes
  • α-Hydroxyketones

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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