Discordant manifestations of hepatitis c in monozygotic twins

Sandro Vento, Lorenza Guella, Ercole Concia

Research output: Contribution to journalLetterpeer-review

1 Citation (Scopus)


To the Editor: The clinical manifestations and evolution of hepatitis C virus (HCV) infection are thought to be influenced by the viral genotype and by the immunoreactivity of the infected person.1 These factors sometimes also determine the appearance of liver–kidney–microsomal autoantibodies type 1 (LKM-1).2 We report discordant manifestations and evolution of HCV infection in a pair of monozygotic twins (with a probability of monozygosity greater than 99 percent).3 One had acute hepatitis and recovered fully. The other had chronic hepatitis associated with the appearance of LKM-1 autoantibodies. The two men, both 20 years of age, share the HLA haplotype A2,11;B8,44;DR3,4;DQ2,3.

Original languageEnglish
Pages (from-to)1224-1225
Number of pages2
JournalNew England Journal of Medicine
Issue number18
Publication statusPublished - Nov 2 1995

ASJC Scopus subject areas

  • Medicine(all)

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