TY - JOUR
T1 - Disease-Associated Qualitative and Quantitative Trait Loci in Proteoglycan-Induced Arthritis and Collagen-Induced Arthritis
AU - Glant, Tibor T.
AU - Adarichev, V. A.
AU - Nesterovitch, A. B.
AU - Szanto, S.
AU - Oswald, J. P.
AU - Jacobs, J. J.
AU - Firneisz, G.
AU - Zhang, J.
AU - Finnegan, A.
AU - Mikecz, K.
PY - 2004/4
Y1 - 2004/4
N2 - Two autoimmune murine models-proteoglycan (aggrecan)-induced arthritis (PGIA) and collagen-induced arthritis (CIA)-were developed in parent strains, F1 and F2 hybrids of major histocompatibility complex (MHC)-matched (H-2 d) BALB/c × DBA/2 and MHC-unmatched (H-2d/H-2 q) BALB/c × DBA/1 intercrosses. The major goal of this comparative study was to identify disease (model)-specific (PGIA or CIA) and shared clinical and immunologic loci in 2 types of genetic intercrosses. Qualitative (binary/susceptibility) and quantitative (severity and onset) clinical trait loci were separated and analyzed independently or together with various pathophysiologic/immunologic traits, such as antigen-specific T- and B-cell responses and cytokine production. The major quantitative trait locus (QTL) was the MHC on chromosome 17, which was especially dominant in CIA. In addition, chromosomes 3, 5, 10, and X contained shared clinical loci in both models, and a total of 8 QTLs (clinical traits together with immunologic traits) were colocalized in PGIA and CIA.
AB - Two autoimmune murine models-proteoglycan (aggrecan)-induced arthritis (PGIA) and collagen-induced arthritis (CIA)-were developed in parent strains, F1 and F2 hybrids of major histocompatibility complex (MHC)-matched (H-2 d) BALB/c × DBA/2 and MHC-unmatched (H-2d/H-2 q) BALB/c × DBA/1 intercrosses. The major goal of this comparative study was to identify disease (model)-specific (PGIA or CIA) and shared clinical and immunologic loci in 2 types of genetic intercrosses. Qualitative (binary/susceptibility) and quantitative (severity and onset) clinical trait loci were separated and analyzed independently or together with various pathophysiologic/immunologic traits, such as antigen-specific T- and B-cell responses and cytokine production. The major quantitative trait locus (QTL) was the MHC on chromosome 17, which was especially dominant in CIA. In addition, chromosomes 3, 5, 10, and X contained shared clinical loci in both models, and a total of 8 QTLs (clinical traits together with immunologic traits) were colocalized in PGIA and CIA.
KW - Arthritis
KW - Collagen-induced arthritis
KW - Genome screen
KW - Proteoglycan-induced arthritis
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=11144358268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144358268&partnerID=8YFLogxK
U2 - 10.1097/00000441-200404000-00004
DO - 10.1097/00000441-200404000-00004
M3 - Article
C2 - 15084914
AN - SCOPUS:11144358268
VL - 327
SP - 188
EP - 195
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 4
ER -