Dissolution characteristics of compressed tablets

Ryusei Ito, Manabu Nishimura, Boris Golman, Kunio Shinohara, Tadashi Fukunaka

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The dissolution rate of medical tablets has hitherto been measured by repeating dissolution tests, which require considerable time to get experimental confirmation of dissolution characteristics. Thus, it has not been investigated from the viewpoint of prescription of the dissolution rate. In this paper, the effects of tablet compaction and primary-particle properties on the dissolution rate were studied experimentally and quantitatively. It was found that the dissolution rate increased with increasing voidage of the tablet, increasing shape index of primary particles, decreasing active component and with decreasing specific surface diameter. The effect of shape index should, therefore, be considered by constructing a new dissolution model, because it is of an equal level to the effect of the specific surface diameter.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalKagaku Kogaku Ronbunshu
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

Keywords

  • Dissolution Characteristics
  • Particle Shape
  • Preparation Parameters
  • Tablet

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Fingerprint Dive into the research topics of 'Dissolution characteristics of compressed tablets'. Together they form a unique fingerprint.

Cite this