Abstract
The dissolution rate of medical tablets has hitherto been measured by repeating dissolution tests, which require considerable time to get experimental confirmation of dissolution characteristics. Thus, it has not been investigated from the viewpoint of prescription of the dissolution rate. In this paper, the effects of tablet compaction and primary-particle properties on the dissolution rate were studied experimentally and quantitatively. It was found that the dissolution rate increased with increasing voidage of the tablet, increasing shape index of primary particles, decreasing active component and with decreasing specific surface diameter. The effect of shape index should, therefore, be considered by constructing a new dissolution model, because it is of an equal level to the effect of the specific surface diameter.
| Original language | English |
|---|---|
| Pages (from-to) | 31-34 |
| Number of pages | 4 |
| Journal | Kagaku Kogaku Ronbunshu |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2005 |
| Externally published | Yes |
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Keywords
- Dissolution Characteristics
- Particle Shape
- Preparation Parameters
- Tablet
ASJC Scopus subject areas
- Materials Science (miscellaneous)
Cite this
Dissolution characteristics of compressed tablets. / Ito, Ryusei; Nishimura, Manabu; Golman, Boris; Shinohara, Kunio; Fukunaka, Tadashi.
In: Kagaku Kogaku Ronbunshu, Vol. 31, No. 1, 01.2005, p. 31-34.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dissolution characteristics of compressed tablets
AU - Ito, Ryusei
AU - Nishimura, Manabu
AU - Golman, Boris
AU - Shinohara, Kunio
AU - Fukunaka, Tadashi
PY - 2005/1
Y1 - 2005/1
N2 - The dissolution rate of medical tablets has hitherto been measured by repeating dissolution tests, which require considerable time to get experimental confirmation of dissolution characteristics. Thus, it has not been investigated from the viewpoint of prescription of the dissolution rate. In this paper, the effects of tablet compaction and primary-particle properties on the dissolution rate were studied experimentally and quantitatively. It was found that the dissolution rate increased with increasing voidage of the tablet, increasing shape index of primary particles, decreasing active component and with decreasing specific surface diameter. The effect of shape index should, therefore, be considered by constructing a new dissolution model, because it is of an equal level to the effect of the specific surface diameter.
AB - The dissolution rate of medical tablets has hitherto been measured by repeating dissolution tests, which require considerable time to get experimental confirmation of dissolution characteristics. Thus, it has not been investigated from the viewpoint of prescription of the dissolution rate. In this paper, the effects of tablet compaction and primary-particle properties on the dissolution rate were studied experimentally and quantitatively. It was found that the dissolution rate increased with increasing voidage of the tablet, increasing shape index of primary particles, decreasing active component and with decreasing specific surface diameter. The effect of shape index should, therefore, be considered by constructing a new dissolution model, because it is of an equal level to the effect of the specific surface diameter.
KW - Dissolution Characteristics
KW - Particle Shape
KW - Preparation Parameters
KW - Tablet
UR - http://www.scopus.com/inward/record.url?scp=15544383372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=15544383372&partnerID=8YFLogxK
U2 - 10.1252/kakoronbunshu.31.31
DO - 10.1252/kakoronbunshu.31.31
M3 - Article
AN - SCOPUS:15544383372
VL - 31
SP - 31
EP - 34
JO - Kagaku Kogaku Ronbunshu
JF - Kagaku Kogaku Ronbunshu
SN - 0386-216X
IS - 1
ER -