Diversification of the 3-benzazepine scaffold applying Ugi/reductive Heck sequence

Anatoly A. Peshkov, Vsevolod A. Peshkov, Olga P. Pereshivko, Erik V. Van Der Eycken

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

A two step sequence involving Ugi reaction followed by reductive Heck cyclization has been evaluated in order to provide access to a 3-benzazepine framework in a diversity-oriented fashion. Several aspects related to the substrate scope and the optimal distribution of the required functional groups have been addressed, resulting in the construction of a small library of the title compounds, featuring four distinct types of substitution pattern.

Original languageEnglish
Pages (from-to)3863-3871
Number of pages9
JournalTetrahedron
Volume71
Issue number23
DOIs
Publication statusPublished - May 26 2015
Externally publishedYes

Keywords

  • 3-Benzazepines
  • Diversity-oriented synthesis
  • Reductive Heck reaction
  • Ugi reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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