Diversity and regulation of amiloride-sensitive Na+ channels

Dale J. Benos, Mouhamed S. Awayda, Bakhram K. Berdiev, Anne Lynn Bradford, Catherine M. Fuller, Oksana Senyk, Iskander I. Ismailov

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Amiloride-sensitive Na+ channels play a vital role in many important physiological processes such as delineation of the final urine composition, sensory transduction, and whole-body Na+ homeostasis. These channels display a wide range of biophysical properties, and are regulated by cAMP-mediated second messenger systems. The first of these channels has recently been cloned. This cloned amiloride-sensitive Na+ channel is termined ENaC (Epithelial Na+ Channel) and, in heterologous cellular expression systems, displays a single channel conductance of 4 to 7 pS, a high P(Na)/P(K) (> 10), a high amiloride sensitivity (K(i)(amil) = 150 nM), and relatively long open and closed times. ENaC may form the core conduction element of many of these functionally diverse forms of Na+ channel. The kinetic and regulatory differences between these channels may be due, in large measure, to unique polypeptides that associate with the core element, forming a functional channel unit.

Original languageEnglish
Pages (from-to)1632-1637
Number of pages6
JournalKidney International
Volume49
Issue number6
Publication statusPublished - 1996
Externally publishedYes

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Amiloride
Epithelial Sodium Channels
Physiological Phenomena
Second Messenger Systems
Homeostasis
Urine
Peptides

ASJC Scopus subject areas

  • Nephrology

Cite this

Benos, D. J., Awayda, M. S., Berdiev, B. K., Bradford, A. L., Fuller, C. M., Senyk, O., & Ismailov, I. I. (1996). Diversity and regulation of amiloride-sensitive Na+ channels. Kidney International, 49(6), 1632-1637.

Diversity and regulation of amiloride-sensitive Na+ channels. / Benos, Dale J.; Awayda, Mouhamed S.; Berdiev, Bakhram K.; Bradford, Anne Lynn; Fuller, Catherine M.; Senyk, Oksana; Ismailov, Iskander I.

In: Kidney International, Vol. 49, No. 6, 1996, p. 1632-1637.

Research output: Contribution to journalArticle

Benos, DJ, Awayda, MS, Berdiev, BK, Bradford, AL, Fuller, CM, Senyk, O & Ismailov, II 1996, 'Diversity and regulation of amiloride-sensitive Na+ channels', Kidney International, vol. 49, no. 6, pp. 1632-1637.
Benos DJ, Awayda MS, Berdiev BK, Bradford AL, Fuller CM, Senyk O et al. Diversity and regulation of amiloride-sensitive Na+ channels. Kidney International. 1996;49(6):1632-1637.
Benos, Dale J. ; Awayda, Mouhamed S. ; Berdiev, Bakhram K. ; Bradford, Anne Lynn ; Fuller, Catherine M. ; Senyk, Oksana ; Ismailov, Iskander I. / Diversity and regulation of amiloride-sensitive Na+ channels. In: Kidney International. 1996 ; Vol. 49, No. 6. pp. 1632-1637.
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