Diversity and regulation of amiloride-sensitive Na+ channels

Dale J. Benos, Mouhamed S. Awayda, Bakhram K. Berdiev, Anne Lynn Bradford, Catherine M. Fuller, Oksana Senyk, Iskander I. Ismailov

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Amiloride-sensitive Na+ channels play a vital role in many important physiological processes such as delineation of the final urine composition, sensory transduction, and whole-body Na+ homeostasis. These channels display a wide range of biophysical properties, and are regulated by cAMP-mediated second messenger systems. The first of these channels has recently been cloned. This cloned amiloride-sensitive Na+ channel is termined ENaC (Epithelial Na+ Channel) and, in heterologous cellular expression systems, displays a single channel conductance of 4 to 7 pS, a high P(Na)/P(K) (> 10), a high amiloride sensitivity (K(i)(amil) = 150 nM), and relatively long open and closed times. ENaC may form the core conduction element of many of these functionally diverse forms of Na+ channel. The kinetic and regulatory differences between these channels may be due, in large measure, to unique polypeptides that associate with the core element, forming a functional channel unit.

Original languageEnglish
Pages (from-to)1632-1637
Number of pages6
JournalKidney International
Volume49
Issue number6
DOIs
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Nephrology

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