E-cadherin and catenins

Molecules with versatile roles in normal and neoplastic epithelial cell biology

Mona A. El-Bahrawy, Massimo Pignatelli

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

E-cadherin and its associated cytoplasmic proteins α-, β-, and γ- catenin, play a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. Perturbation in the expression or function of any of these molecules results in loss of intercellular adhesion, with possible consequent cell transformation and tumour progression. The catenins are connected to many structural and functional proteins, which in turn influence their functions. Among these molecules are type I growth factor receptors, which along with other molecules are believed to alter the function of catenins through tyrosine phosphorylation. A recent finding is the association between the catenins and the adenomatous polyposis coli gene product (APC). APC mutation is an early event in colorectal carcinogenesis. It may possibly do so through perturbation of the critical cadherin/catenin complex. Further studies of the cadherin/catenin complex and its connections may give insight into the early molecular interactions critical to the initiation and progression of tumours, which should aid in the development of novel therapeutic strategies for both prevention and treatment.

Original languageEnglish
Pages (from-to)224-232
Number of pages9
JournalMicroscopy Research and Technique
Volume43
Issue number3
DOIs
Publication statusPublished - Nov 1 1998
Externally publishedYes

Fingerprint

Cytology
Catenins
cadherins
Cadherins
cell biology
Cell Biology
epithelial cells
Epithelial Cells
progressions
Molecules
Tumors
adhesion
tumors
proteins
Proteins
molecules
development aid
perturbation
phosphorylation
Phosphorylation

Keywords

  • Adhesion
  • Cancer
  • Differentiation
  • Growth factor receptors
  • Invasion
  • Tumour progression

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

E-cadherin and catenins : Molecules with versatile roles in normal and neoplastic epithelial cell biology. / El-Bahrawy, Mona A.; Pignatelli, Massimo.

In: Microscopy Research and Technique, Vol. 43, No. 3, 01.11.1998, p. 224-232.

Research output: Contribution to journalArticle

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