E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis

Andrea Buda, Massimo Pignatelli

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Abnormalities in the expression and functional activity of cell adhesion molecules are implicated in the development and progression of the majority of colorectal cancers (CRC). Cellcell adhesion molecule E-cadherin regulates cell polarity, differentiation, proliferation and migration through its intimate association to the actin cytoskeletal network. During colorectal carcinogenesis changes in intercellular adhesion and dynamic rearrangements in the actin cytoskeleton result in altered signalling and migration with loss of contact inhibition. The adenomatous polyposis coli (APC) protein, besides its established role in the β catenin/Wnt signalling pathway, can coordinate microtubule and actin organization during cell migration. The actin-bundling protein Fascin promotes cell motility and is overexpressed in CRC. Based on recent molecular and pathological studies, this review focusses on the role of these molecules sharing the common feature of being associated with the cytoskeletal network during colorectal carcinogenesis and metastasis. The potential use of these molecules as prognostic markers and/or therapeutic targets will also be discussed.

Original languageEnglish
Pages (from-to)133-143
Number of pages11
JournalCell Communication and Adhesion
Volume18
Issue number6
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

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Cadherins
Cell Movement
Actins
Colorectal Neoplasms
Neoplasm Metastasis
Carcinogenesis
Adenomatous Polyposis Coli Protein
Contact Inhibition
Molecules
Catenins
Cell Polarity
Wnt Signaling Pathway
Adhesion
Cell Adhesion Molecules
Actin Cytoskeleton
Microtubules
Cell Differentiation
Proteins
Therapeutics

Keywords

  • adhesion molecules
  • APC
  • colorectal cancer
  • Cytoskeleton
  • E-cadherin
  • Fascin

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry

Cite this

E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis. / Buda, Andrea; Pignatelli, Massimo.

In: Cell Communication and Adhesion, Vol. 18, No. 6, 12.2011, p. 133-143.

Research output: Contribution to journalArticle

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