Abstract
Abnormalities in the expression and functional activity of cell adhesion molecules are implicated in the development and progression of the majority of colorectal cancers (CRC). Cellcell adhesion molecule E-cadherin regulates cell polarity, differentiation, proliferation and migration through its intimate association to the actin cytoskeletal network. During colorectal carcinogenesis changes in intercellular adhesion and dynamic rearrangements in the actin cytoskeleton result in altered signalling and migration with loss of contact inhibition. The adenomatous polyposis coli (APC) protein, besides its established role in the β catenin/Wnt signalling pathway, can coordinate microtubule and actin organization during cell migration. The actin-bundling protein Fascin promotes cell motility and is overexpressed in CRC. Based on recent molecular and pathological studies, this review focusses on the role of these molecules sharing the common feature of being associated with the cytoskeletal network during colorectal carcinogenesis and metastasis. The potential use of these molecules as prognostic markers and/or therapeutic targets will also be discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 133-143 |
| Number of pages | 11 |
| Journal | Cell Communication and Adhesion |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2011 |
| Externally published | Yes |
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Keywords
- adhesion molecules
- APC
- colorectal cancer
- Cytoskeleton
- E-cadherin
- Fascin
ASJC Scopus subject areas
- Cell Biology
- Clinical Biochemistry
Cite this
E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis. / Buda, Andrea; Pignatelli, Massimo.
In: Cell Communication and Adhesion, Vol. 18, No. 6, 12.2011, p. 133-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis
AU - Buda, Andrea
AU - Pignatelli, Massimo
PY - 2011/12
Y1 - 2011/12
N2 - Abnormalities in the expression and functional activity of cell adhesion molecules are implicated in the development and progression of the majority of colorectal cancers (CRC). Cellcell adhesion molecule E-cadherin regulates cell polarity, differentiation, proliferation and migration through its intimate association to the actin cytoskeletal network. During colorectal carcinogenesis changes in intercellular adhesion and dynamic rearrangements in the actin cytoskeleton result in altered signalling and migration with loss of contact inhibition. The adenomatous polyposis coli (APC) protein, besides its established role in the β catenin/Wnt signalling pathway, can coordinate microtubule and actin organization during cell migration. The actin-bundling protein Fascin promotes cell motility and is overexpressed in CRC. Based on recent molecular and pathological studies, this review focusses on the role of these molecules sharing the common feature of being associated with the cytoskeletal network during colorectal carcinogenesis and metastasis. The potential use of these molecules as prognostic markers and/or therapeutic targets will also be discussed.
AB - Abnormalities in the expression and functional activity of cell adhesion molecules are implicated in the development and progression of the majority of colorectal cancers (CRC). Cellcell adhesion molecule E-cadherin regulates cell polarity, differentiation, proliferation and migration through its intimate association to the actin cytoskeletal network. During colorectal carcinogenesis changes in intercellular adhesion and dynamic rearrangements in the actin cytoskeleton result in altered signalling and migration with loss of contact inhibition. The adenomatous polyposis coli (APC) protein, besides its established role in the β catenin/Wnt signalling pathway, can coordinate microtubule and actin organization during cell migration. The actin-bundling protein Fascin promotes cell motility and is overexpressed in CRC. Based on recent molecular and pathological studies, this review focusses on the role of these molecules sharing the common feature of being associated with the cytoskeletal network during colorectal carcinogenesis and metastasis. The potential use of these molecules as prognostic markers and/or therapeutic targets will also be discussed.
KW - adhesion molecules
KW - APC
KW - colorectal cancer
KW - Cytoskeleton
KW - E-cadherin
KW - Fascin
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UR - http://www.scopus.com/inward/citedby.url?scp=84855433363&partnerID=8YFLogxK
U2 - 10.3109/15419061.2011.636465
DO - 10.3109/15419061.2011.636465
M3 - Article
C2 - 22176698
AN - SCOPUS:84855433363
VL - 18
SP - 133
EP - 143
JO - Cell Communication and Adhesion
JF - Cell Communication and Adhesion
SN - 1541-9061
IS - 6
ER -