E-Cadherin (E-cad) expression in duct carcinoma in situ (DCIS) of the breast

S. K. Gupta, A. G. Douglas-Jones, B. Jasani, J. M. Morgan, M. Pignatelli, R. E. Mansel

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51 Citations (Scopus)

Abstract

E-cadherin (E-cad) is an epithelial cell-cell adhesion molecule whose loss or reduced expression is associated with a more invasive tumour phenotype. Ninety-six cases of screen detected pure ductal carcinoma in situ (DCIS) were analysed immunocytochemically for expression of E-cad using the HECD-1 mouse monoclonal antibody. The in situ component in each case was classified on the basis of cytonuclear grade, extent of necrosis, Van Nuys classification and a newly devised Cardiff classification. The amount of E-cad expression was assessed semi-quantitatively using an intensity distribution method. There is significantly more expression of E-cad in well-differentiated DCIS when compared with poorly differentiated DCIS and this finding is highly significant (P<0.001) irrespective of the classification system used. These findings suggest that progressive loss of E-cad expression may occur at an early stage of breast cancer development.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalVirchows Archiv
Volume430
Issue number1
DOIs
Publication statusPublished - Feb 21 1997

Keywords

  • Adhesion molecules
  • Breast
  • Duct carcinoma of breast
  • E-cadherin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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    Gupta, S. K., Douglas-Jones, A. G., Jasani, B., Morgan, J. M., Pignatelli, M., & Mansel, R. E. (1997). E-Cadherin (E-cad) expression in duct carcinoma in situ (DCIS) of the breast. Virchows Archiv, 430(1), 23-28. https://doi.org/10.1007/BF01008012