E-Cadherin (E-cad) expression in duct carcinoma in situ (DCIS) of the breast

S. K. Gupta, A. G. Douglas-Jones, B. Jasani, J. M. Morgan, M. Pignatelli, R. E. Mansel

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


E-cadherin (E-cad) is an epithelial cell-cell adhesion molecule whose loss or reduced expression is associated with a more invasive tumour phenotype. Ninety-six cases of screen detected pure ductal carcinoma in situ (DCIS) were analysed immunocytochemically for expression of E-cad using the HECD-1 mouse monoclonal antibody. The in situ component in each case was classified on the basis of cytonuclear grade, extent of necrosis, Van Nuys classification and a newly devised Cardiff classification. The amount of E-cad expression was assessed semi-quantitatively using an intensity distribution method. There is significantly more expression of E-cad in well-differentiated DCIS when compared with poorly differentiated DCIS and this finding is highly significant (P<0.001) irrespective of the classification system used. These findings suggest that progressive loss of E-cad expression may occur at an early stage of breast cancer development.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalVirchows Archiv
Issue number1
Publication statusPublished - 1997


  • Adhesion molecules
  • Breast
  • Duct carcinoma of breast
  • E-cadherin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'E-Cadherin (E-cad) expression in duct carcinoma in situ (DCIS) of the breast'. Together they form a unique fingerprint.

Cite this