TY - JOUR
T1 - Eag1 K+ Channel
T2 - Endogenous Regulation and Functions in Nervous System
AU - Han, Bo
AU - Tokay, Tursonjan
AU - Zhang, Guangming
AU - Sun, Peng
AU - Hou, Shangwei
N1 - Funding Information:
The authors thank Dr. Toshinori Hoshi (the University of Pennsylvania) for carefully reading the manuscript. This work was supported by National Natural Science Foundation of China (31271217), National Basic Research Program of China (2014CB910304), Shanghai Science and Technology Commission (11JC1406400, 12PJ1404200), and State Key Laboratory of Oncogenes and Related Genes Grant (90-12-03).
Publisher Copyright:
© 2017 Bo Han et al.
PY - 2017
Y1 - 2017
N2 - Ether-à-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.
AB - Ether-à-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.
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U2 - 10.1155/2017/7371010
DO - 10.1155/2017/7371010
M3 - Review article
AN - SCOPUS:85016082837
SN - 1942-0900
VL - 2017
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 7371010
ER -