Eag1 K+ Channel

Endogenous Regulation and Functions in Nervous System

Bo Han, Tursonjan Tokay, Guangming Zhang, Peng Sun, Shangwei Hou

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Ether-à-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.

Original languageEnglish
Article number7371010
JournalOxidative Medicine and Cellular Longevity
Volume2017
DOIs
Publication statusPublished - 2017

Fingerprint

Voltage-Gated Potassium Channels
Neurology
Nervous System
Ion Channels
Ether
Oxidation-Reduction
Tumors
Reactive Oxygen Species
Neoplasms
Central Nervous System
Cells
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

Cite this

Eag1 K+ Channel : Endogenous Regulation and Functions in Nervous System. / Han, Bo; Tokay, Tursonjan; Zhang, Guangming; Sun, Peng; Hou, Shangwei.

In: Oxidative Medicine and Cellular Longevity, Vol. 2017, 7371010, 2017.

Research output: Contribution to journalReview article

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abstract = "Ether-{\`a}-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.",
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